α-MSH

Cat. No. 2584

alpha-MSH Ac-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2

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Alternative Names: α-Melanotropin, α-Melanocyte-stimulating hormone

Biological Activity

Endogenous melanocortin receptor agonist (Ki values are 0.12, 31, 660 and 5700 nM for MC1, MC3, MC4 and MC5 receptors respectively). Anti-inflammatory peptide; antagonizes proinflammatory mediators, including TNF-α, IL-6 and NO and induces anti-inflammatory cytokine IL-10. Inhibits food intake and induces penile erections following i.c.v. administration.

Technical Data

M.Wt:
1664.9
Formula:
C77H109N21O19S
Sequence:
SYSMEHFRWGKPV

(Modifications: Ser-1 = N-terminal Ac, Val-13 = C-terminal amide)

Solubility:
Soluble to 0.60 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
581-05-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Yamaoka-Tojo et al (2006) Central neurotranspeptide, alpha-melanocyte-stimulating hormone (α-MSH) is upregulated in patients with congestive heart failure. Intern.Med. 45 429. PMID: 16679696.

Mizusawa et al (2002) Alpha-melanocyte stimulating hormone and oxytocin induced penile erections, and intracavernous pressure increases in the rat. J.Urol. 167 757. PMID: 11792967.

Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 295. PMID: 10443584.

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Keywords: alpha-MSH, supplier, Endogenous, melanocortin, receptor, agonists, MC, Receptors, Melanocortin, α-MSH, alpha-MSH, α-Melanocyte-stimulating, alpha-Melanocyte-stimulating, hormone, α-Melanotropin, alpha-Melanotropin, a-MSH, Tocris Bioscience, Melanocortin (MC) Receptor Agonist products

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Appetite Modulation

Written by S. Tucci et al

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