ML 9 hydrochloride

Cat. No. 0431

ML 9 hydrochloride C15H17ClN2O2S.HCl [105637-50-1]

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Chemical Name: 1-(5-Chloronaphthalenesulfonyl)homopiperazine hydrochloride

Biological Activity

Selective MLCK inhibitor (Ki values are 4, 32 and 54 μM for MLCK, PKA and PKC respectively). Also inhibits STIM1-plasma membrane interactions, preventing store-operated Ca2+ entry (SOCE).

Technical Data

M.Wt:
361.29
Formula:
C15H17ClN2O2S.HCl
Solubility:
Soluble to 25 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
105637-50-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Varnai et al (2009) STIM and Orai: the long-awaited constituents of store-operated calcium entry. TiPS 30 118. PMID: 19187978.

Hidaka and Koybashi (1992) Pharmacology of protein kinase inhibitors. Annu.Rev.Pharmacol.Toxicol. 32 377. PMID: 1605572.

Seto et al (1991) Effects of HA1077, a protein kinase inhibitor, on myosin phosphorylation and tension in smooth muscle. Eur.J.Pharmacol. 195 267. PMID: 1874276.

Hidaka and Hagiwara (1987) Pharmacology of the isoquinoline sulfonamide protein kinase C inhibitors. Trends Pharmacol.Sci. 8 162.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for ML 9 hydrochloride include:

Dobson et al (2015) Caffeine Modulates Vesicle Release and Recovery at Cerebellar Parallel Fibre Terminals, Independently of Calcium and Cyclic AMP Signalling. J Pharmacol Exp Ther 10 e0125974. PMID: 25933382.

Siddoway et al (2013) An essential role for inhibitor-2 regulation of protein phosphatase-1 in synaptic scaling. PLoS One 33 11206. PMID: 23825423.

Do you know of a great paper that uses ML 9 hydrochloride from Tocris? If so please let us know.

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Keywords: ML 9 hydrochloride, supplier, Myosin, light, chain, kinase, inhibitors, inhibits, STIM1-plasma, membrane, interaction, Kinases, Ca2+, Binding, Protein, modulators, Calmodulin, CaM, Calcium, Signaling, Signalling, Store, Operated, Channels, STIM-Orai, ML9, hydrochloride, MLCK, Tocris Bioscience, Myosin Light Chain Kinase Inhibitor products

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