(-)-MK 801 maleate

Cat. No. 0955

(-)-MK 801 maleate C16H15N.C4H4O4 [121917-57-5]

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Chemical Name: (5R,10S)-(-)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cylcohepten-5,10-imine maleate

Biological Activity

Less active enantiomer (10-fold less potent in behavioral studies) than (+)-MK 801 maleate (Cat. No. 0924).

Technical Data

M.Wt:
337.37
Formula:
C16H15N.C4H4O4
Solubility:
Soluble to 25 mM in water with gentle warming
Purity:
>99 %
Storage:
Store at RT
CAS No:
121917-57-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Genovese and Lu (1991) Effects of MK-801 stereoisomers on schedule-controlled behavior in rats. Psychopharmacology. 105 477. PMID: 1771215.

Thompson et al (1990) Synthesis and pharmacological evaluation of a series of dibenzo[a,d]cycloalkenimines as N-Methyl-D-aspartate antagonists. J.Med.Chem. 33 789. PMID: 1688947.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (-)-MK 801 maleate include:

Yang et al (2005) Behavioral stress enhances hippocampal CA1 long-term depression through the blockade of the glutamate uptake. J Pharmacol Exp Ther 25 4288. PMID: 15858055.

Huang et al (2004) Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci 24 4551. PMID: 15140926.

Do you know of a great paper that uses (-)-MK 801 maleate from Tocris? If so please let us know.

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