Lansoprazole

Cat. No. 2582

Lansoprazole C16H14F3N3O2S [103577-45-3]

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Alternative Name: AG-1749

Chemical Name: 2-[[[3-Methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole

Biological Activity

H+,K+-ATPase inhibitor (IC50 = 6.3 μM) that displays antisecretory and antiulcer activity. Inhibits gastric acid secretion (IC50 = 0.09 μM for histamine-induced acid formation) and reduces gastric lesion formation induced by a variety of ulcerative stimuli. Antibacterial against Helicobacter pylori in vitro. Also blocks swelling-dependent chloride channel (ICIswell) in NIH3T3 fibroblasts. More potent than omeprazole (Cat. No. 2583).

Technical Data

M.Wt:
369.36
Formula:
C16H14F3N3O2S
Solubility:
Soluble to 50 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at +4°C
CAS No:
103577-45-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Matheson and Jarvis (2001) Lansoprazole. Drugs 61 1801. PMID: 11693467.

Schmarda et al (2000) The gastric H,K-ATPase blocker lansoprazole is an inhibitor of chloride channels. Br.J.Pharmacol. 129 598. PMID: 10711360.

Satoh et al (1989) Antisecretory and antiulcer activities of a novel proton pump inhibitor AG-1749 in dogs and rats. J.Pharmacol.Exp.Ther. 248 806. PMID: 2537418.

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Keywords: Lansoprazole, supplier, H+K+-ATPase, inhibitors, inhibits, Hydrogen, Potassium-ATPase, Ion, Transporters, Pumps, ATPases, AG1749, Tocris Bioscience, H+,K+-ATPase Inhibitor products

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