Cat. No. 0771
Chemical Name: NG-Monomethyl-L-arginine acetate
Biological ActivityCompetitive, irreversible inhibitor of all three NOS isoforms.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Reif and McCreedy et al (1995) N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a differential pattern of inactivation toward the three nitric oxide synthases. Arch.Biochem.Biophys. 320 170. PMID: 7540822.
Olken et al (1991) Inactivation of macrophage nitric oxide synthase activity by N(G)-methyl-L-arginine. Biochem.Biophys.Res.Commun. 177 828. PMID: 2049105.
Rees et al (1990) Characterisation of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro. Br.J.Pharmacol. 101 746. PMID: 1706208.
Saksuma et al (1988) Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc.Natl.Acad.Sci.U.S.A. 85 8664. PMID: 3263652.
If you know of a relevant reference for L-NMMA acetate please let us know.
Citations are publications that use Tocris products. Selected citations for L-NMMA acetate include:
Schophuizen et al (2015) Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. J Neurosci 4 234. PMID: 26132391.
Echeverría et al (2014) Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS One 9 e94146. PMID: 24710004.
Do you know of a great paper that uses L-NMMA acetate from Tocris? If so please let us know.
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Keywords: L-NMMA acetate, supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, NO, Synthases, nNOS, iNOS, eNOS, Tocris Bioscience, Non-selective NOS Inhibitor products