L-NMMA acetate

Cat. No. 0771

L-NMMA acetate C7H16N4O2.CH3CO2H [53308-83-1]

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Chemical Name: NG-Monomethyl-L-arginine acetate

Biological Activity

Competitive, irreversible inhibitor of all three NOS isoforms.

Technical Data

M.Wt:
248.28
Formula:
C7H16N4O2.CH3CO2H
Solubility:
Soluble to 50 mM in water
Storage:
Desiccate at RT
CAS No:
53308-83-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Reif and McCreedy et al (1995) N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a differential pattern of inactivation toward the three nitric oxide synthases. Arch.Biochem.Biophys. 320 170. PMID: 7540822.

Olken et al (1991) Inactivation of macrophage nitric oxide synthase activity by N(G)-methyl-L-arginine. Biochem.Biophys.Res.Commun. 177 828. PMID: 2049105.

Rees et al (1990) Characterisation of three inhibitors of endothelial nitric oxide synthase in vivo and in vitro. Br.J.Pharmacol. 101 746. PMID: 1706208.

Saksuma et al (1988) Identification of arginine as a precursor of endothelium-derived relaxing factor. Proc.Natl.Acad.Sci.U.S.A. 85 8664. PMID: 3263652.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for L-NMMA acetate include:

Schophuizen et al (2015) Uremic Toxins Induce ET-1 Release by Human Proximal Tubule Cells, which Regulates Organic Cation Uptake Time-Dependently. J Neurosci 4 234. PMID: 26132391.

Echeverría et al (2014) Endotoxin induces fibrosis in vascular endothelial cells through a mechanism dependent on transient receptor protein melastatin 7 activity. PLoS One 9 e94146. PMID: 24710004.

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Keywords: L-NMMA acetate, supplier, Non-Selective, NOS, inhibitors, inhibits, Nitric, Oxide, Signaling, Signalling, NO, Synthases, nNOS, iNOS, eNOS, Tocris Bioscience, Non-selective NOS Inhibitor products

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