PAC 1

Cat. No. 2581

PAC 1 C23H28N4O2 [315183-21-2]

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Chemical Name: 4-(Phenylmethyl)-1-piperazineacetic acid [[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide

Biological Activity

Procaspase-activating compound; activates procaspase-3 to produce caspase-3 (EC50 = 0.22 μM). Also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). Pro-apoptotic; induces apoptosis in both cancerous and non-cancerous cells dependent on procaspase-3 concentration (IC50 values are 0.003 - 1.41 and 5.02 - 9.98 μM respectively).

Technical Data

M.Wt:
392.5
Formula:
C23H28N4O2
Solubility:
Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
315183-21-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Peterson et al (2009) Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3. J.Med.Chem. 52 5721. PMID: 19708658.

Putt et al (2006) Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat.Chem.Biol. 2 543. PMID: 16936720.

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Keywords: PAC 1, supplier, activators, procaspase-3, proapoptotic, Caspases, Proteinases, Proteases, PAC1, Tocris Bioscience, Caspase Activator products

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