Cetirizine dihydrochloride

Cat. No. 2577

Cetirizine dihydrochloride C21H25ClN2O3.2HCl [83881-52-1]

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Alternative Name: P 071

Chemical Name: [2-[4-[(4-Chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]acetic acid dihydrochloride

Biological Activity

Histamine H1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Walsh et al (1991) Effects of cetirizine on human eosinophil and neutrophil activation in vitro. Int.Arch.Allergy Appl.Immunol. 95 158. PMID: 1682275.

Campoli-Richards et al (1990) Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria. Drugs 40 762. PMID: 1981354.

Snowman and Snyder (1990) Cetirizine: actions on neurotransmitter receptors. J.Allergy.Clin.Immunol. 86 1025. PMID: 1979798.

If you know of a relevant reference for Cetirizine dihydrochloride please let us know.

Citations are publications that use Tocris products. Selected citations for Cetirizine dihydrochloride include:

Ito et al (2015) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. PLoS One 11 547. PMID: 25714760.

Kemp et al (2014) DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem 289 26574. PMID: 25107903.

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149. PMID: 23626477.

Do you know of a great paper that uses Cetirizine dihydrochloride from Tocris? If so please let us know.

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Keywords: Cetirizine dihydrochloride, supplier, Selective, H1, antagonists, Receptors, Histamine, histaminergic, P071, Tocris Bioscience, Histamine H1 Receptor Antagonist products

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