Cat. No. 2577
Alternative Name: P 071
Chemical Name: [2-[4-[(4-Chlorophenyl)phenylmethyl
Biological ActivityHistamine H1 receptor antagonist that displays selectivity over other receptors at concentrations up to 10 μM. A non-sedating antihistamine that inhibits histamine release and eosinophil chemotaxis during secondary phase allergic response. Inhibits activation of eosinophils, neutrophils and monocytes in vivo.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Walsh et al (1991) Effects of cetirizine on human eosinophil and neutrophil activation in vitro. Int.Arch.Allergy Appl.Immunol. 95 158. PMID: 1682275.
Campoli-Richards et al (1990) Cetirizine. A review of its pharmacological properties and clinical potential in allergic rhinitis, pollen-induced asthma, and chronic urticaria. Drugs 40 762. PMID: 1981354.
Snowman and Snyder (1990) Cetirizine: actions on neurotransmitter receptors. J.Allergy.Clin.Immunol. 86 1025. PMID: 1979798.
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Citations are publications that use Tocris products. Selected citations for Cetirizine dihydrochloride include:
Ito et al (2015) PARK2-mediated mitophagy is involved in regulation of HBEC senescence in COPD pathogenesis. PLoS One 11 547. PMID: 25714760.
Kemp et al (2014) DNA repair synthesis and ligation affect the processing of excised oligonucleotides generated by human nucleotide excision repair. J Biol Chem 289 26574. PMID: 25107903.
Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149. PMID: 23626477.
Do you know of a great paper that uses Cetirizine dihydrochloride from Tocris? If so please let us know.
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Keywords: Cetirizine dihydrochloride, supplier, Selective, H1, antagonists, Receptors, Histamine, histaminergic, P071, Tocris Bioscience, Histamine H1 Receptor Antagonist products
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