Hemokinin 1 (human)

Cat. No. 2576

Hemokinin 1 (human) Thr-Gly-Lys-Ala-Ser-Gln-Phe-Phe-Gly-Leu-Met-NH2

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Biological Activity

Endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.

Technical Data

M.Wt:
1185.4
Formula:
C54H84N14O14S
Sequence:
TGKASQFFGLM

(Modifications: Met- 11= C-terminal amide)

Solubility:
Soluble to 0.70 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
491851-53-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Bellucci et al (2002) Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 135 266. PMID: 11786503.

Kurtz et al (2002) Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Gene 296 205. PMID: 12383518.

Zhang et al (2000) Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nature Immunol. 1 392.

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Keywords: Hemokinin 1 (human), supplier, Endogenous, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, Hemokinin1, (human), Tocris Bioscience, NK1 Receptor Agonist products

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