Cat. No. 2575
Chemical Name: N-[(2R)-4-Hydroxyamino)-1,4-dioxo-2
Biological ActivityInhibitor of the major neurotensin and neuromedin N degrading enzymes (IC50 values are 31, 40, 52 and 58 nM for endopeptidase 24.15, endopeptidase 24.11, leucine aminopeptidase and endopeptidase 24.16 respectively). Exhibits analgesic effects in various nociception assays.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Menard et al (1996) The cytotoxic activity of Bacillus anthracis lethal factor is inhibited by leukotriene A4 hydrolase and metallopeptidase inhibitors. Biochem.J. 320 687. PMID: 8973585.
Doulut et al (1993) Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes. J.Med.Chem. 36 1369. PMID: 8496905.
Kitabgi et al (1992) Effects of thiorphan, bestatin and a novel metallopeptidase inhibitor JMV 390-1 on the recovery of neurotensin and neuromedin N released from mouse hypothalamus. Neurosci.Lett. 142 200. PMID: 1454216.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products.
Do you know of a great paper that uses JMV 390-1 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: JMV 390-1, supplier, JMV390-1, endopeptidases, 24.15, 24.11, 24.16, inhibitors, inhibits, neurotensin, neuromedin, n, analgesics, Tocris Bioscience, Other Protease Inhibitor products
Find multiple products by catalog number
New Products in this Area
High affinity angiotensin-converting enzyme (ACE) ligandTMI 1
Adam 17 (TACE) and MMP inhibitor; orally bioavailableRitonavir
HIV-1 and HIV-2 protease inhibitorAcetyl Pepstatin
High affinity aspartic protease inhibitor; inhibits HIV-1/2 proteinasesONO 6818
High affinity and selective human neutraphil elastase 1 (HNE1) inhibitor; orally active
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.