Kisspeptin 10 (human)

Cat. No. 2570

Kisspeptin 10 (human) Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2

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Alternative Names: Metastin (45-54), Kp-10

Biological Activity

Potent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.

Technical Data

M.Wt:
1302.45
Formula:
C63H83N17O14
Sequence:
YNWNSFGLRF

(Modifications: Phe-10 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
374675-21-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Peilecka-Fortuna et al (2007) Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by estradiol. Endocrinology 149 1979. PMID: 18162521.

Becker et al (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors. Biochem.Biophys.Res.Comm. 326 677.

Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631. PMID: 11457843.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Kisspeptin 10 (human) include:

Schwetz et al (2014) Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10. PLoS One 9 e113020. PMID: 25401335.

Wu et al (2013) Kisspeptin-10 enhanced egg production in quails associated with the increase of triglyceride synthesis in liver. Asian-Australas J Anim Sci 26 1080. PMID: 25049888.

Wu et al (2012) Effects of kisspeptin-10 on lipid metabolism in cultured chicken hepatocytes. Asian-Australas J Anim Sci 25 1229. PMID: 25049685.

Do you know of a great paper that uses Kisspeptin 10 (human) from Tocris? If so please let us know.

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Keywords: Kisspeptin 10 (human), supplier, Endogenous, ligands, KISS1, receptors, hOT7T175/AXOR12/GPR54, Metastin, KISS-derived, Peptide, Kisspeptin10, Tocris Bioscience, Kisspeptin Receptor Agonist products

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