Kisspeptin 10 (human)
Cat. No. 2570
Alternative Names: Metastin (45-54), Kp-10
Biological ActivityPotent endogenous ligand for the Kisspeptin receptor (KISS1, GPR54). Binds with high affinity to rat and human KISS1 receptors with Ki values of 1.59 and 2.33 nM respectively. Inhibits metastasis and invasion in mouse melanomas and stimulates gonadotropin secretion following i.c.v. administration.
(Modifications: Phe-10 = C-terminal amide)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Peilecka-Fortuna et al (2007) Kisspeptin acts directly and indirectly to increase GnRH neuron activity and its effects are modulated by estradiol. Endocrinology 149 1979. PMID: 18162521.
Becker et al (2005) Activation of GPR54 promotes cell cycle arrest and apoptosis of human tumour cells through a specific transcriptional program not shared by other Gq-coupled receptors. Biochem.Biophys.Res.Comm. 326 677.
Kotani et al (2001) The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54. J.Biol.Chem. 276 34631. PMID: 11457843.
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Citations are publications that use Tocris products. Selected citations for Kisspeptin 10 (human) include:
Ji et al (2014) Implication of metastasis suppressor gene, Kiss-1 and its receptor Kiss-1R in colorectal cancer. Autophagy 14 723. PMID: 25260785.
Schwetz et al (2014) Differential stimulation of insulin secretion by GLP-1 and Kisspeptin-10. PLoS One 9 e113020. PMID: 25401335.
Wu et al (2013) Kisspeptin-10 enhanced egg production in quails associated with the increase of triglyceride synthesis in liver. Asian-Australas J Anim Sci 26 1080. PMID: 25049888.
Wu et al (2012) Effects of kisspeptin-10 on lipid metabolism in cultured chicken hepatocytes. Asian-Australas J Anim Sci 25 1229. PMID: 25049685.
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Keywords: Kisspeptin 10 (human), supplier, Endogenous, ligands, KISS1, receptors, hOT7T175/AXOR12/GPR54, Metastin, KISS-derived, Peptide, Kisspeptin10, Tocris Bioscience, Kisspeptin Receptor Agonist products
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