Cat. No. 2569
Biological ActivitySelective, high affinity angiotensin AT2 receptor ligand (Ki = 0.24 nM). Displays agonistic properties at proximal tubule AT2 receptors, causes Na+, K+-ATPase inhibition and sodium excretion. Antagonizes Ang-II induced contractions in rabbit aortic rings (IC50 = 1850 nM).
(Modifications: Tyr-1 = N-α-Nicotinoyl, Lys-2 = Lys-(N-α-Z-Arg))
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Hakam and Hussain (2006) Angiotensin II AT2 receptors inhibit proximal tubular Na+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am.J.Physiol.Renal Physiol. 290 F1430. PMID: 16380464.
Naveri (1995) The role of angiotensin receptor subtypes in cerebrovascular regulation in the rat. Acta.Physiol.Scand.Suppl. 630 1. PMID: 8610501.
Criscione et al (1990) Binding characteristics and vascular effects of various angiotensin II antagonists. J.Cardiovas.Pharmacol. 16 (Suppl. 4) S56.
If you know of a relevant reference for CGP 42112 please let us know.
Citations are publications that use Tocris products. Selected citations for CGP 42112 include:
Raffai et al (2016) Angiotensin-(1-7) selectively induces relaxation and modulates endothelium-dependent dilation in mesenteric arteries of salt-fed rats Journal of Vascular Research 53 105. PMID: 27676088.
Li et al (2012) Perinatal nicotine exposure increases vulnerability of hypoxic-ischemic brain injury in neonatal rats: role of angiotensin II receptors. BMC Cancer 43 2483. PMID: 22738920.
Nostramo et al (2012) Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. Stroke 215 291. PMID: 22911895.
Do you know of a great paper that uses CGP 42112 from Tocris? If so please let us know.
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Keywords: CGP 42112, supplier, Selective, high, affinity, AT2, ligands, Receptors, Angiotensin, CGP42112, Tocris Bioscience, Angiotensin AT2 Receptor products
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May 17 - 19, 2017