PLP (139-151)

Cat. No. 2567

PLP (139-151) His-Ser-Leu-Gly-Lys-Trp-Leu-Gly-His-Pro-Asp-Lys-Phe

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Alternative Name: Proteolipid protein (139-151)

Biological Activity

Synthetic myelin proteolipid protein (PLP) fragment. Immunization with this peptide induces severe clinical and histological experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis.

Technical Data

M.Wt:
1521.74
Formula:
C72H104N20O17
Sequence:
HSLGKWLGHPDKF
Solubility:
Soluble to 2 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
122018-58-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Kuchroo et al (1991) Induction of experimental allergic encephalomyelitis by myelin proteolipid-protein-specific T cell clones and synthetic peptides. Pathobiology. 59 305. PMID: 1716908.

Sobel et al (1990) Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein. J.Neuropathol.Exp.Neurol. 49 468. PMID: 2273404.

Tuohy et al (1989) Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. J.Immunol. 142 1523. PMID: 2465343.

If you know of a relevant reference for PLP (139-151) please let us know.

Citations are publications that use Tocris products. Selected citations for PLP (139-151) include:

Arima et al (2015) A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model. Elife 4. PMID: 26193120.

Jana et al (2012) Gemfibrozil, a lipid-lowering drug, increases myelin genes in human oligodendrocytes via peroxisome proliferator-activated receptor-β. J Biol Chem 287 34134. PMID: 22879602.

Mondal et al (2012) Regulation of encephalitogenicity of neuroantigen-primed T cells by nitric oxide: Implications for multiple sclerosis. J Clin Cell Immunol 3 124. PMID: 23275862.

Do you know of a great paper that uses PLP (139-151) from Tocris? If so please let us know.

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Keywords: PLP (139-151), supplier, Encephalitogenic, myelin, proteolipid, fragment, Neuronal, Metabolism, multiple, sclerosis, encephalomyelitis, EAE, Tocris Bioscience, Neuronal Metabolism products

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