Melanotan II

Cat. No. 2566

Melanotan II Ac-Nle-cyclo(β-Asp-His-D-Phe-Arg-Trp-ε-Lys)-NH2

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Alternative Name: MT-II

Biological Activity

High affinity melanocortin receptor agonist (Ki values are 0.67, 6.6, 34 and 46 nM for MC1, MC4, MC3 and MC5 receptors respectively). Stimulates erectile activity, inhibits food intake and displays neuroprotective properties in vivo.

Technical Data

M.Wt:
1024.19
Formula:
C50H69N15O9
Sequence:
XDHFRWK

(Modifications: X = Nle & N-terminal Ac, Asp-2 = beta-Asp, Phe-4 = D-Phe, Lys-7 = epsilon-Lys, Cyclized = Asp-2 - Lys-7, C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
121062-08-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Ter Laak et al (2003) The potent melanocortin receptor agonist melanotan-II promotes peripheral nerve regeneration and has neuroprotective properties in the rat. Eur.J.Pharmacol. 462 179. PMID: 12591111.

Martin et al (2002) Activation of melanocortin MC4 receptors increases erectile activity in rats ex copula. Eur.J.Pharmacol. 454 71. PMID: 12409007.

Wikber (1999) Melanocortin receptors: perspectives for novel drugs. Eur.J.Pharmacol. 375 395.

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Keywords: Melanotan II, supplier, High, affinity, melanocortin, receptor, agonists, MC, Receptors, MelanotanII, Tocris Bioscience, Melanocortin (MC) Receptor Agonist products

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