ZK 756326

Cat. No. 2565

ZK 756326 C21H28N2O3.2HCl [874911-96-3]

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Chemical Name: 2-[2-[4-[(3-phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride

Biological Activity

Selective, non-peptide CCR8 chemokine receptor agonist (IC50 values are 1.8 and 2.6 μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at α2A and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.

Technical Data

M.Wt:
429.38
Formula:
C21H28N2O3.2HCl
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
874911-96-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Haskell et al (2006) Identification and characterization of a potent, selective nonpeptide agonist of the CC chemokine receptor CCR8. Mol.Pharmacol. 69 309. PMID: 16221874.

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Keywords: ZK 756326, supplier, Selective, non-peptide, CCR8, agonists, CXCR, Chemokine, Receptors, ZK756326, Tocris Bioscience, Chemokine CC Receptor Agonist products

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