AM 114

Cat. No. 2564

AM 114 C20H21B2NO5 [856849-35-9]

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Chemical Name: 3,5-Bis-[benzylidene-4-boronic acid]-1-methylpiperidin-4-one

Biological Activity

Inhibitor of the chymotrypsin-like activity of the 20S proteasome (IC50 ~ 1 μM). Displays anticancer activity; inhibits cell growth in human colon cancer HCT116 p53+/+ cells (IC50 = 1.49 μM).

Licensing Information

Sold with the permission of Johns Hopkins University

Technical Data

Soluble to 10 mM in DMSO
>97 %
Store at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Achanta et al (2006) A boronic-chalcone derivative exhibits potent anticancer activity through inhibition of the proteasome. Mol.Pharmacol. 70 426. PMID: 16636137.

Achanta et al (2005) Preferential killing of cancer cells with wild-type p53 by boronic chalcones. Proc.Am.Assoc.Cancer Res.Abstr. 46 6162.

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Keywords: AM 114, supplier, 20S, proteasome, inhibitors, inhibits, Proteinases, Proteases, AM114, Tocris Bioscience, Proteasome Inhibitor products

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