Fexaramine

Cat. No. 2563

Fexaramine C32H36N2O3 [574013-66-4]

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Chemical Name: 3-[3-[(Cyclohexylcarbonyl)-[[4'-(dimethylamino)-[1,1'-biphenyl]-4-yl]methyl]amino]phenyl]-2-propenoic acid methyl ester

Biological Activity

Potent, selective farnesoid X receptor agonist (EC50 = 25 nM). Displays no activity at hRXRα, hPPARα, hPPARγ, hPPARδ, mPXR, hPXR, hLXRα, hTRβ, hRARβ, mCAR, mERRγ and hVDR receptors.

Technical Data

M.Wt:
496.64
Formula:
C32H36N2O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
>97 %
Storage:
Desiccate at +4°C
CAS No:
574013-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Pellicciari et al (2006) Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. J.Med.Chem. 49 4208. PMID: 16821780.

Downes et al (2003) A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR. Mol.Cell 11 1079. PMID: 12718892.

Nicolaou et al (2003) Discovery and optimization of non-steroidal FXR agonists from natural product-like libraries. Org.Biomol.Chem. 1 908. PMID: 12929628.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Fexaramine include:

Nagiec et al (2015) Modulators of hepatic lipoprotein metabolism identified in a search for small-molecule inducers of tribbles pseudokinase 1 expression. J Endocrinol 10 e0120295. PMID: 25811180.

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View Related Products by Product Action

Keywords: Fexaramine, supplier, Potent, selective, farnesoid, X, receptor, FXR, agonists, Receptors, Liver, Farnesoid, LXR-like, Tocris Bioscience, LXR-like Receptor Agonist products

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