PB 28 dihydrochloride

Cat. No. 2562

PB 28 dihydrochloride C24H38N2O.2HCl [172907-03-8]

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Chemical Name: 1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazine dihydrochloride

Biological Activity

High affinity σ2 receptor agonist (Ki values are 0.8 and 15.2 nM for σ2 and σ1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC50 values are 2.62 and 3.96 μM respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.

Technical Data

Soluble to 20 mM in water with gentle warming
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Colabufo et al (2004) Antiproliferative and cytotoxic effects of some σ2 agonists and σ1 antagonists in tumour cell lines. Naunyn-Schmied.Arch.Pharmacol. 370 106.

Colabufo et al (2003) A new method for evaluating σ2 ligand activity in the isolated guinea-pig bladder. Naunyn-Schmied.Arch.Pharmacol. 368 106.

Berardi et al (1996) New σ and 5-HT1A receptor ligands: ω-(tetralin-1-yl)-n-alkylamine derivatives. J.Med.Chem. 39 176. PMID: 8568804.

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Keywords: PB 28 dihydrochloride, supplier, High, affinity, σ2, sigma2, agonists, Receptors, PB28, dihydrochloride, Tocris Bioscience, σ2 Receptor Agonist products

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