Cat. No. 2561
Alternative Name: R 24571
Chemical Name: 1-[Bis(4-chlorophenyl)methyl]-3-[2-
Biological ActivityCalmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca2+-transporting ATPase with IC50 values of 0.15 and 0.35 μM respectively. Also causes elevation of intracellular calcium in HL-60 cells, independent of calmodulin inhibition.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Peppiatt et al (2004) Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells. Biochem.J. 381 929. PMID: 15130089.
Harper and Daly (2000) Effect of calmidazolium analogs on calcium influx in HL-60 cells. Biochem.Pharmacol. 60 317. PMID: 10856426.
Gietzen (1983) Comparison of the calmodulin antagonists compound 48/80 and calmidazolium. Biochem.J. 216 611. PMID: 6141789.
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Citations are publications that use Tocris products. Selected citations for Calmidazolium chloride include:
Varadarajan et al (2013) Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PLoS One 8 e56603. PMID: 23457590.
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Keywords: Calmidazolium chloride, supplier, Calmodulin, antagonists, Ca2+, Binding, Protein, modulators, Calcium, Signaling, Signalling, R24571, Tocris Bioscience, Calcium Binding Protein Modulator Antagonist products