2-Methyl-5-hydroxytryptamine hydrochloride

Cat. No. 0558

2-Methyl-5-hydroxytryptamine hydrochloride C11H14N2O.HCl [845861-49-6]

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Biological Activity

5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM).

Technical Data

M.Wt:
226.71
Formula:
C11H14N2O.HCl
Solubility:
Soluble to 100 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
845861-49-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011. PMID: 10715164.

Craig et al (1990) 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn Schmiedebergs Arch.Pharmacol. 342 9. PMID: 2402303.

Ismaiel et al (1990) 5-HT1 and 5-HT2 binding profiles of the serotonergic agents α-methyl serotonin and 2-methylserotonin. J.Med.Chem. 33 755. PMID: 2299641.

Wilson et al (1990) 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 252 683. PMID: 1968974.

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Keywords: 2-Methyl-5-hydroxytryptamine hydrochloride, supplier, 5-HT3, agonists, potent, 5-HT6, ligand, Serotonin, Receptors, 2-Me-5HT, 2, methyl5HT, Tocris Bioscience, 5-HT3 Receptor Agonist products

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5-HT Review

Written by N. Barnes & J. Neumaler

5-HT Receptors Scientific Review

Our 5-HT review summarizes the serotonin receptor subtypes and highlights their importance in mediating various physiological & pharmacological processes. Request copy or view PDF today.

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