Cat. No. 0558
Biological Activity5-HT3 agonist (Ki = 1200 nM) and potent 5-HT6 ligand (Ki = 46 nM).
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Glennon et al (2000) 2-substituted tryptamines: agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011. PMID: 10715164.
Craig et al (1990) 5-Methoxytryptamine and 2-methyl-5-hydroxytryptamine-induced desensitization as a discriminative tool for the 5-HT3 and putative 5-HT4 receptors in guinea pig ileum. Naunyn Schmiedebergs Arch.Pharmacol. 342 9. PMID: 2402303.
Ismaiel et al (1990) 5-HT1 and 5-HT2 binding profiles of the serotonergic agents α-methyl serotonin and 2-methylserotonin. J.Med.Chem. 33 755. PMID: 2299641.
Wilson et al (1990) 5-Hydroxytryptamine3 receptors mediate tachycardia in conscious instrumented dogs. J.Pharmacol.Exp.Ther. 252 683. PMID: 1968974.
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Citations are publications that use Tocris products.
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