10-DEBC hydrochloride

Cat. No. 2558

10-DEBC hydrochloride C20H25N2OCl.HCl [925681-41-0]

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Chemical Name: 10-[4'-(N,N-Diethylamino)butyl]-2-chlorophenoxazine hydrochloride

Biological Activity

Selective inhibitor of Akt/PKB. Inhibits IGF-1-stimulated phosphorylation and activation of Akt (complete inhibition at 2.5 μM), suppressing downstream activation of mTOR, p70 S6 kinase and S6 ribosomal protein. Shows no activity at PDK1, SGK1 or PI 3-kinase. Inhibits cell growth (IC50 ~ 2-6 μM) and induces apoptosis in rhabdomyosarcoma cells.

Technical Data

Soluble to 100 mM in water and to 100 mM in DMSO
>99 %
Desiccate at +4°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Thimmaiah et al (2005) Identification of N10-substituted phenoxazines as potent and specific inhibitors of Akt signaling. J.Biol.Chem. 36 31924.

Thimmaiah et al (1992) Synthesis and chemical characterization of N-substituted phenoxazines directed toward reversing vinca alkaloid resistance in multidrug-resistant cancer cells. J.Med.Chem. 35 3358. PMID: 1527786.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 10-DEBC hydrochloride include:

Sokołowska et al (2014) Orexins protect neuronal cell cultures against hypoxic stress: an involvement of Akt signaling. PLoS One 52 48. PMID: 24243084.

Gangoiti et al (2012) Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts. Biochimie 94 597. PMID: 21945811.

Goodnough et al (2012) Inhibition of hepcidin transcription by growth factors. Hepatology 56 291. PMID: 22278715.

Do you know of a great paper that uses 10-DEBC hydrochloride from Tocris? If so please let us know.

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Keywords: 10-DEBC hydrochloride, supplier, Selective, Akt, PKB, inhibitors, inhibits, Protein, Kinase, B, Kinases, Tocris Bioscience, Akt (Protein Kinase B) Inhibitor products

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