PNU 109291

Cat. No. 2556

PNU 109291 C24H31N3O3 [187665-60-7]

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Chemical Name: (S)-3,4-Dihydro-1-[2-[4-(4-methoxyphenyl)-1-piperazinyl]ethyl]-N-methyl-1H-2-benzopyran-6-carboxamide

Biological Activity

Potent and selective 5-HT1D receptor agonist that displays > 600-fold selectivity over 5-HT1A and 5-HT2A receptors and no activity at 5-HT1B, 5-HT1E, 5-HT2B, 5-HT2C, 5-HT6 and 5-HT7 receptors. Reduces dural plasma extravasation evoked by trigeminal ganglion stimulation.

Technical Data

M.Wt:
409.52
Formula:
C24H31N3O3
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
187665-60-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Bhattacharya et al (2004) 5-Hydroxytryptamine1B receptor-mediated contraction of rabbit saphenous vein and basilar artery: role of vascular endothelium. J.Pharmacol.Exp.Ther. 309 825. PMID: 14724223.

Cutrer et al (1999) Effects of PNU-109,291, a selective 5-HT1D receptor agonist, on electrically induced dural plasma extravasation and capsaicin-evoked c-fos immunoreactivity within trigeminal nucleus caudalis. Neuropharmacology 38 1043. PMID: 10428423.

Ennis et al (1998) Isochroman-6-carboxamides as highly selective 5-HT1D agonists: potential new treatment for migraine without cardiovascular side effects. J.Med.Chem. 41 2180. PMID: 9632349.

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Citations are publications that use Tocris products. Selected citations for PNU 109291 include:

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. J Mol Neurosci 3 e00103. PMID: 25692021.

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Keywords: PNU 109291, supplier, Potent, selective, 5-HT1D, agonists, Serotonin, Receptors, PNU109291, Tocris Bioscience, 5-HT1D Receptor Agonist products

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