Nα-Methylhistamine dihydrochloride

Cat. No. 0573

N-Methylhistamine dihydrochloride C6H11N3.2HCl [16503-22-3]

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Chemical Name: N-Methyl-1H-imidazole-4-ethanamine dihydrochloride

Biological Activity

Potent histamine agonist, particularly at H3 receptors (potency relative to histamine is 81, 185, and 270% at H1, H2 and H3 respectively). Also displays agonist properties at H4 receptors to which it binds with moderate affinity (Ki = 23 nM).

Technical Data

M.Wt:
198.09
Formula:
C6H11N3.2HCl
Solubility:
Soluble to 100 mM in water
Storage:
Desiccate at RT
CAS No:
16503-22-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Zweig et al (1992) Characterization of digitonin-solubilized bovine brain H3 histamine receptor coupled to a guanine nucleotide-binding protein. J.Neurochem. 59 1661. PMID: 1328529.

Hill et al (1990) Distribution, properties, and functional characteristics of three classes of histamine receptor. Pharmacol.Rev. 42 45. PMID: 2164693.

Schwartz et al (1990) A third histamine receptor subtype - characterization, localization and functions of the H3-receptor. Agents Actions 30 13. PMID: 1695431.

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Keywords: N-Methylhistamine dihydrochloride, supplier, Non-Selective, H3, agonists, Receptors, Histamine, histaminergic, Nalpha-Methylhistamine, dihydrochloride, Tocris Bioscience, Histamine H3 Receptor Agonist products

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