(R)-(-)-α-Methylhistamine dihydrobromide

Cat. No. 0569

(R)-(-)-a-Methylhistamine dihydrobromide C6H11N3.2HBr [868698-49-1]

Price and Availability

For (R)-(-)-α-Methylhistamine dihydrobromide pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: (R)-(-)-α-Methyl-1H-imidazole-4-ethanamine dihydrobromide

Biological Activity

Very potent, high affinity H3 agonist (KD = 50.3 nM) that displays > 200-fold selectivity over H4 receptors. Inhibits H3-mediated histamine synthesis and release in the CNS and stimulates H4-mediated eosinophil shape change (EC50 = 66 nM). Part of the Histamine H3 Receptor Tocriset™. (S)-(+)-α-Methylhistamine dihydrobromide (Cat. No. 0572) also available.

Technical Data

M.Wt:
287
Formula:
C6H11N3.2HBr
Solubility:
Soluble to 100 mM in water
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
868698-49-1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Select another batch:
Safety Data Sheet: View Safety Data Sheet

Shahid et al (2009) Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9.

Buckland et al (2003) Histamine induces cytoskeletal changes in human eosinophils via the H4 receptor. Br.J.Pharmacol. 140 1117. PMID: 14530216.

Hew et al (1990) Characterization of histamine-H3 receptors in guinea pig ileum with H3-selective ligands. Br.J.Pharmacol. 101 621. PMID: 1963802.

Schwartz et al (1990) A third histamine receptor subtype - characterization, localization and functions of the H3-receptor. Agents Actions 30 13. PMID: 1695431.

Oishi et al (1989) Effects of histamine H3-agonist (R)-α-methylhistamine and the antagonist thioperamide on histamine modulation in the mouse and rat brain. J.Neurochem. 52 1388. PMID: 2540269.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for (R)-(-)-α-Methylhistamine dihydrobromide include:

Kim et al (2013) Effects of histamine on cultured interstitial cells of cajal in murine small intestine. Korean J Physiol Pharmacol 17 149. PMID: 23626477.

Do you know of a great paper that uses (R)-(-)-α-Methylhistamine dihydrobromide from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: (R)-(-)-a-Methylhistamine dihydrobromide, supplier, Potent, H3, agonists, Receptors, Histamine, histaminergic, (R)-(-)-alpha-Methylhistamine, dihydrobromide, Tocris Bioscience, Histamine H3 Receptor Agonist products

Quick Order

Find multiple products by catalog number

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

divider line

Histamine Review

Written by I. de Esch & R. Leurs

Histamine Receptors Scientific Review

Our Histamine review gives an overview of the different histamine receptor subtypes, as well as highlighting pharmacological ligands for their study. View PDF today.

divider line

New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

divider line

Alzheimer's Disease: Neurobiology and Drug Targets

Written by Alan Palmer

Alzheimer's Life Science Poster

Our Alzheimer's disease poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease. Request copy or view PDF today.

divider line

New Products in this Area

Desloratadine

High affinity H1 antagonist; anti-inflammatory.

Sign-up for new product e-alerts
divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.