SYM 2081

Cat. No. 0903

SYM 2081 C6H11NO4 [31137-74-3]

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Chemical Name: (2S,4R)-4-Methylglutamic acid

Biological Activity

Potent and highly selective kainate receptor agonist, with an IC50 for inhibition of [3H]-kainate binding of 35 nM and almost 3,000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. Also selectively inhibits the cloned excitatory amino acid transporter EAAT2 at higher concentrations. Also available as part of the Excitatory Amino Acid Transporter Inhibitor Tocriset™ and Kainate Receptor Tocriset™.

Licensing Information

Sold with the permission of Annovis Inc.

Technical Data

Soluble to 50 mM in water
>97 %
Store at RT

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Savidge et al (1999) Characterisation of kainate receptor mediated whole-cell currents in rat cultured cerebellar granule cells. Neuropharmacology 38 375. PMID: 10219975.

Donevan et al (1998) The methylglutamate, SYM 2081, is a potent and highly selective agonist at kainate receptors. J.Pharmacol.Exp.Ther. 285 539. PMID: 9580595.

Jones et al (1997) Desensitization of kainate receptors by kainate, glutamate and diastereomers of 4-methylglutamate. Neuropharmacology 36 853. PMID: 9225313.

Zhou et al (1997) (2S,4R)-4-Methylglutamic acid (SYM 2081): a selective, high affinity ligand for kainate receptors. J.Pharmacol.Exp.Ther. 280 422. PMID: 8996224.

If you know of a relevant reference for SYM 2081 please let us know.

Citations are publications that use Tocris products. Selected citations for SYM 2081 include:

Yoshii et al (2013) A Myosin Va mutant mouse with disruptions in glutamate synaptic development and mature plasticity in visual cortex. Addict Biol 33 8472. PMID: 23658184.

Santos et al (2009) Transmission efficacy and plasticity in glutamatergic synapses formed by excitatory interneurons of the substantia gelatinosa in the rat spinal cord. PLoS One 4 e8047. PMID: 19956641.

Do you know of a great paper that uses SYM 2081 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: SYM 2081, supplier, inhibitors, inhibits, EAAT2, kainate, receptors, agonist, selective, EAAT, Excitatory, Amino, Acid, Transporters, GLT-1, Glutamate, Monoamine, Neurotransmitter, iGluR, Ionotropic, SYM2081, Tocris Bioscience, Kainate Receptor Agonist products

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