Calcitriol

Cat. No. 2551

Calcitriol C27H44O3 [32222-06-3]

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Alternative Name: 1,25-Dihydroxyvitamin D3

Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol

Biological Activity

Active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Technical Data

M.Wt:
416.64
Formula:
C27H44O3
Solubility:
Soluble in DMSO and in ethanol
Purity:
>99 %
Storage:
Desiccate at -20°C
CAS No:
32222-06-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589. PMID: 16873882.

Beer and Myrthue (2004) Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373. PMID: 15026558.

Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. PMID: 11004217.

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Keywords: Calcitriol, supplier, Vitamin, D, receptor, VDR, agonists, Receptors, VDR-like, 1,25-DihydroxyvitaminD3, Tocris Bioscience, Vitamin D Receptor Agonist products

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