Cat. No. 2551

Calcitriol C27H44O3 [32222-06-3]

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Alternative Name: 1,25-Dihydroxyvitamin D3

Chemical Name: (1α,3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol

Biological Activity

Active metabolite of vitamin D3 that activates the vitamin D receptor (VDR). Displays calcemic actions; stimulates intestinal and renal Ca2+ absorption and regulates bone Ca2+ turnover. Exhibits antitumor activity; inhibits in vivo and in vitro cell proliferation in a wide range of cells including breast, prostate, colon, skin and brain carcinomas and myeloid leukemia cells.

Technical Data

Soluble in DMSO and in ethanol
>99 %
Desiccate at -20°C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Nijenhuis et al (2006) The novel vitamin D analog ZK191784 as an intestine-specific vitamin D antagonist. FASEB J. 20 1589. PMID: 16873882.

Beer and Myrthue (2004) Calcitriol in cancer treatment: from the lab to the clinic. Mol.Cancer Ther. 3 373. PMID: 15026558.

Canalejo et al (2000) The in vitro effect of calcitriol on parathyroid cell proliferation and apoptosis. J.Am.Soc.Nephrol. 11 1865. PMID: 11004217.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Calcitriol include:

Sharma et al (2015) A novel cytostatic form of autophagy in sensitization of non-small cell lung cancer cells to radiation by vitamin D and the vitamin D analog, EB 1089. Atherosclerosis 10 2346. PMID: 25629933.

Pal et al (2010) Osteocalcin positive mononuclear cells are associated with the severity of aortic calcification. J Neurosci 210 88. PMID: 20004897.

Do you know of a great paper that uses Calcitriol from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: Calcitriol, supplier, Vitamin, D, receptor, VDR, agonists, Receptors, VDR-like, 1,25-DihydroxyvitaminD3, Tocris Bioscience, Vitamin D Receptor Agonist products

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