Cat. No. 2549
Alternative Name: z-Pseudosubstrate inhibitory peptide
Biological ActivityNovel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Control and biotinylated peptides (Cat. Nos. 3215 and 3290) also available.
(Modifications: Ser-1 = Myr-Ser)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141. PMID: 16931766.
Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979. PMID: 15728837.
Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for ZIP include:
Chen et al (2015) Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity. Mol Pain 113 3047. PMID: 25761958.
Han et al (2015) Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury. J Neurophysiol 2015 601767. PMID: 26457205.
Lee et al (2013) Prkcz null mice show normal learning and memory. Nature 493 416. PMID: 23283171.
Laferrière et al (2011) PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain. Autophagy 7 99. PMID: 22185613.
Balaban et al Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix. Front Cell Neurosci 9 222. PMID: 26157359.
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Keywords: ZIP, supplier, Cell-permeable, inhibitors, inhibits, atypical, PKC, isozyme, PKMzeta, Protein, Kinases, C, Tocris Bioscience, Protein Kinase C Inhibitor products
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