Cat. No. 2549
Alternative Name: z-Pseudosubstrate inhibitory peptide
Biological ActivityNovel, cell-permeable inhibitor of protein kinase Mζ (PKMζ), a constitutively active, atypical PKC isozyme involved in LTP maintenance. Selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. Reverses late-phase LTP (IC50 = 1 - 2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Control and biotinylated peptides (Cat. Nos. 3215 and 3290) also available.
(Modifications: Ser-1 = Myr-Ser)
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Pastalkova et al (2006) Storage of spatial information by the maintenance mechanism of LTP. Science 313 1141. PMID: 16931766.
Serrano et al (2005) Persistent phosphorylation by protein kinase Mz maintains late-phase long-term potentiation. J.Neurosci. 25 1979. PMID: 15728837.
Ling et al (2002) Protein kinase Mz is necessary and sufficient for LTP maintenance. Nature Neurosci. 5 295.
If you know of a relevant reference for ZIP please let us know.
Citations are publications that use Tocris products. Selected citations for ZIP include:
Chen et al (2015) Involvement of protein kinase ζ in the maintenance of hippocampal long-term potentiation in rats with chronic visceral hypersensitivity. Mol Pain 113 3047. PMID: 25761958.
Han et al (2015) Plasticity-Related PKMζ Signaling in the Insular Cortex Is Involved in the Modulation of Neuropathic Pain after Nerve Injury. J Neurophysiol 2015 601767. PMID: 26457205.
Lee et al (2013) Prkcz null mice show normal learning and memory. Nature 493 416. PMID: 23283171.
Laferrière et al (2011) PKMζ is essential for spinal plasticity underlying the maintenance of persistent pain. Autophagy 7 99. PMID: 22185613.
Balaban et al Homolog of protein kinase Mζ maintains context aversive memory and underlying long-term facilitation in terrestrial snail Helix. Front Cell Neurosci 9 222. PMID: 26157359.
View Related Products by Product Action
Keywords: ZIP, supplier, Cell-permeable, inhibitors, inhibits, atypical, PKC, isozyme, PKMzeta, Protein, Kinases, C, Tocris Bioscience, Protein Kinase C Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent and selective Brk inhibitorCVT 313
High affinity PKC activator; also APP modulatorJH 295
Irreversible Nek2 inhibitorOXSI 2
Potent Syk kinase inhibitor; also inhibits assembly of NLRP3 inflammasomesSTK16-IN-1
Serine/threonine protein kinase 16 (STK16) inhibitor; also inhibits PI 3Kδ, PI 3Kγ and mTOR kinases.AZ PFKFB3 26
Potent and selective PFKFB3 inhibitorNCL 00017509
Potent and reversible NIMA related kinase 2 (Nek2) inhibitorXMD 8-87
Potent Ack1/TNK2 inhibitorSKI 178
Non-lipid sphingosine kinase 1 (SphK1) inhibitorML 315 hydrochloride
Inhibitor of Clk and DYRK kinasesEverolimus
mTOR inhibitor;immunosuppressantPKI (5-24)
High affinity PKA inhibitorTDZD 8
Selective non-ATP competitive inhibitor of GSK 3βBI 605906
Selective IKKβ inhibitorGSK 319347A
Potent and selective IKKε inhibitorFRAX 597
Potent group I PAK inhibitorMRT 68921 dihydrochloride
Potent ULK inhibitor; inhibits autophagyAM 2394
Potent glucokinase activator; orally bioavailableeCF 309
Potent mTOR inhibitorPF 3758309 dihydrochloride
Potent PAK4 inhibitor; orally availableAZ Dyrk1B 33
Potent and selective Dyrk1B kinase inhibitorPF 06409577
Potent and selective allosteric activator of AMPK
Win a $1,000 travel grant
Bio-Techne is offering 10 travel grants of $1,000 for Neuroscience 2017.