(±)-threo-3-Methylglutamic acid

Cat. No. 0811

()-threo-3-Methylglutamic acid C6H11NO4 [63088-04-0]

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Biological Activity

A potent blocker of glutamate transport; selective for EAAT2 and EAAT4 (IC50 values are 90, 109, 1600 and 1080 μM for EAAT2, EAAT4, EAAT1 and EAAT3 respectively).

Technical Data

M.Wt:
161.16
Formula:
C6H11NO4
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
>98 %
Storage:
Store at RT
CAS No:
63088-04-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Eliasof et al (2001) Pharmacological characterization of threo-3-methylglutamic acid with excitatory amino acid transporters in native and recombinant systems. J.Neurochem. 77 550. PMID: 11299317.

Mitrovic et al (1998) Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. J.Biol.Chem. 273 14698. PMID: 9614067.

Vandenberg et al (1997) Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Mol.Pharmacol. 51 809. PMID: 9145919.

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Citations are publications that use Tocris products.

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Keywords: ()-threo-3-Methylglutamic acid, supplier, EAAT2, EAAT4, blockers, Excitatory, Amino, Acid, Transporters, GLT-1, Glutamate, Monoamine, Neurotransmitter, Tocris Bioscience, Glutamate Transporter Inhibitor products

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