6-Hydroxydopamine hydrobromide

Cat. No. 2547

6-Hydroxydopamine hydrobromide C8H11NO3.HBr [636-00-0]

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Alternative Name: 6-OHDA

Chemical Name: 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide

Biological Activity

Selective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.

Technical Data

M.Wt:
250.09
Formula:
C8H11NO3.HBr
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Storage:
Desiccate at -20°C
CAS No:
636-00-0

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Fujita et al (2006) Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 1113 10. PMID: 16945353.

Soto-Otero et al (2000) Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J.Neurochem. 74 1605. PMID: 10737618.

Breese and Traylor (1970) Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: evidence for selective degeneration of catecholamine neurons. J.Pharmacol.Exp.Ther. 174 413. PMID: 5456173.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for 6-Hydroxydopamine hydrobromide include:

Grau and Greene (2012) Use of PC12 cells and rat superior cervical ganglion sympathetic neurons as models for neuroprotective assays relevant to Parkinson's disease. Methods Mol Biol 846 201. PMID: 22367813.

Malagelada et al (2010) Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J Neurosci 30 1166. PMID: 20089925.

Malagelada et al (2008) RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation. J Neurosci 28 14363. PMID: 19118169.

Do you know of a great paper that uses 6-Hydroxydopamine hydrobromide from Tocris? If so please let us know.

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Keywords: 6-Hydroxydopamine hydrobromide, supplier, Selective, catecholaminergic, neurotoxin, Dopamine, Receptors, adrenoceptors, adrenergic, dopaminergic, neurotoxins, parkinson's, parkinsons, Tocris Bioscience, Dopaminergic-Related products

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