Cat. No. 2547
Alternative Name: 6-OHDA
Chemical Name: 5-(2-Aminoethyl)-1,2,4-benzenetriol
Biological ActivitySelective catecholaminergic neurotoxin. Depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. Causes almost complete destruction of nigral dopaminergic neurons and their striatal terminals when injected into the substantia nigra of rats, producing an animal model of Parkinson's disease.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Fujita et al (2006) Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 1113 10. PMID: 16945353.
Soto-Otero et al (2000) Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J.Neurochem. 74 1605. PMID: 10737618.
Breese and Traylor (1970) Effect of 6-hydroxydopamine on brain norepinephrine and dopamine: evidence for selective degeneration of catecholamine neurons. J.Pharmacol.Exp.Ther. 174 413. PMID: 5456173.
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Citations are publications that use Tocris products. Selected citations for 6-Hydroxydopamine hydrobromide include:
Sérriàre et al (2015) Assessment of the Protection of Dopaminergic Neurons by an α7 Nicotinic Receptor Agonist, PHA 543613 Using [(18)F]LBT-999 in a Parkinson's Disease Rat Model. PLoS One 2 61. PMID: 26389120.
Reinhardt et al (2013) Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling. Neural Plast 8 e59252. PMID: 23533608.
Fouillet et al (2012) ER stress inhibits neuronal death by promoting autophagy. Front Med (Lausanne) 8 915. PMID: 22660271.
Grau and Greene (2012) Use of PC12 cells and rat superior cervical ganglion sympathetic neurons as models for neuroprotective assays relevant to Parkinson's disease. Methods Mol Biol 846 201. PMID: 22367813.
Malagelada et al (2010) Rapamycin protects against neuron death in in vitro and in vivo models of Parkinson's disease. J Neurosci 30 1166. PMID: 20089925.
Malagelada et al (2008) RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/activation. J Neurosci 28 14363. PMID: 19118169.
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Keywords: 6-Hydroxydopamine hydrobromide, supplier, Selective, catecholaminergic, neurotoxin, Dopamine, Receptors, adrenoceptors, adrenergic, dopaminergic, neurotoxins, parkinson's, parkinsons, Tocris Bioscience, Dopaminergic-Related products