PKI 14-22 amide, myristoylated

Cat. No. 2546

PKI 14-22 amide, myristoylated Myr-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2

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Alternative Name: Protein kinase inhibitor-(14-22)-amide, myristoylated

Biological Activity

Cell-permeable version of protein kinase inhibitor PKI (14-22) amide. The non-myristoylated version inhibits protein kinase A (Ki = 36 nM), inhibits cell growth and induces apoptosis in human pancreatic cancer cells (PANC-1).

Technical Data

M.Wt:
1209.5
Formula:
C53H100N20O12
Sequence:
GRTGRRNAI

(Modifications: Gly-1 = Myr-Gly, Ile-9 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in 30% acetonitrile / water
Storage:
Desiccate at -20°C
CAS No:
201422-03-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

Certificate of Analysis / Product Datasheet
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References are publications that support the products' biological activity.

Farrow et al (2003) Inhibition of pancreatic cancer cell growth and induction of apoptosis with novel therapies directed against protein kinase A. Surgery 134 197. PMID: 12947318.

Zheng et al (2000) Activation of apolipoprotein AI gene expression by protein kinase A and kinase C through transcription factor, Sp1. J.Biol.Chem. 275 31747. PMID: 10829013.

Glass et al (1989) Primary structural determinants essential for potent inhibition of cAMP-dependent protein kinase by inhibitory peptides corresponding to the active portion of the heat-stable inhibitory protein. J.Biol.Chem. 264 8802. PMID: 2722799.

If you know of a relevant reference for PKI 14-22 amide, myristoylated please let us know.

Citations are publications that use Tocris products. Selected citations for PKI 14-22 amide, myristoylated include:

Muñoz-Llancao et al (2015) Exchange Protein Directly Activated by cAMP (EPAC) Regulates Neuronal Polarization through Rap1B. J Exp Med 35 11315. PMID: 26269639.

Singh et al (2015) The Orphan G Protein-Coupled Receptor Gpr175 (TPRA40) Enhances Hedgehog Signaling by Modulating cAMP Levels. J Biol Chem NULL. PMID: 26451044.

Watson et al (2015) Endothelial CD99 signals through soluble adenylyl cyclase and PKA to regulate leukocyte transendothelial migration. J Biol Chem 212 1021. PMID: 26101266.

Adelfinger et al (2014) GABAB receptor phosphorylation regulates KCTD12-induced K+ current desensitization. Biochem Pharmacol 91 369. PMID: 25065880.

Okumura et al (2014) Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase. PLoS One 9 e100559. PMID: 24945349.

Maddugoda et al (2011) cAMP signaling by anthrax edema toxin induces transendothelial cell tunnels, which are resealed by MIM via Arp2/3-driven actin polymerization. Cell Host Microbe 10 464. PMID: 22100162.

Meitzen et al (2011) β1-Adrenergic receptors activate two distinct signaling pathways in striatal neurons. J Neurochem 116 984. PMID: 21143600.

Tseng et al (2010) PKA-induced receptor activator of NF-κB ligand (RANKL) expression in vascular cells mediates osteoclastogenesis but not matrix calcification. Autophagy 285 29925. PMID: 20663885.

Liu et al (2008) Restoration of lysosomal pH in RPE cells from cultured human and ABCA4(-/-) mice: pharmacologic approaches and functional recovery. Invest Ophthalmol Vis Sci 49 772. PMID: 18235027.

Do you know of a great paper that uses PKI 14-22 amide, myristoylated from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: PKI 14-22 amide, myristoylated, supplier, Cell-permeable, protein, kinases, A, inhibitors, inhibits, Cell, permeable, PKA, PKI14-22, amide, myristoylated, Tocris Bioscience, Protein Kinase A Inhibitor products

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