Nafarelin

Cat. No. 2544

Nafarelin Glp-His-Trp-Ser-Tyr-D-2NaI-Leu-Arg-Pro-Gly-NH2

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Biological Activity

Synthetic gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Repeated administration causes desensitization of pituitary GnRH receptors resulting in inhibition of gonadotropin release and decreased steroid hormone synthesis. Induces atrophy and regression of experimentally induced endometriosis in rat and shrinks hypertrophic tissue in benign prostatic hyperplasia.

Technical Data

M.Wt:
1322
Formula:
C66H83N17O13
Sequence:
XEHWSYXLRPG

(Modifications: X-1 = Glp, X-2 = 2-Nal, Gly-10 = C-terminal amide)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
76932-56-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Mizutani et al (1995) Effect of gonadotrophin-releasing hormone agonists, nafarelin, buserelin, and leuprolide, on experimentally induced endometriosis in the rat. Int.J.Fertil.Menopausal Stud. 40 106. PMID: 7599657.

Chrisp and Goa (1990) Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions. Drugs 39 523. PMID: 2140979.

Letassy et al (1990) Nafarelin acetate: a gonadotrophin-releasing hormone agonist for the treatment of endometriosis. DICP 24 1204. PMID: 2151003.

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Keywords: Nafarelin, supplier, GnRH, receptor, agonists, Receptors, Gonadotrophin-Releasing, Hormone, gonadotropin, Tocris Bioscience, Gonadotropin-Releasing Hormone Receptor Agonist products

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