Sarafotoxin S6c

Cat. No. 1175

Sarafotoxin S6c Cys-Thr-Cys-Asn-Asp-Met-Thr-Asp-Glu-Glu-Cys-Leu-Asn-Phe-Cys-His-Gln-Asp-Val-Ile-Trp

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Biological Activity

Highly selective ETB endothelin receptor agonist (Ki values are 0.29 and 28000 nM at ETB and ETA receptors respectively).

Technical Data

M.Wt:
2516
Formula:
C103H147N27O37S5
Sequence:
CTCNDMTDEECLNFCHQDVIW

(Modifications: Disulfide bridge between 1 - 15, 3 - 11)

Solubility:
Soluble to 1 mg/ml in water
Storage:
Desiccate at -20°C
CAS No:
121695-87-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Miasiro et al (1998) Distinct endothelin-B receptors mediate the effects of sarafotoxin S6c and IRL 1620 in the ileum. J.Cardiovasc.Pharmacol. 31 S175. PMID: 9595431.

Matsuo et al (1997) Effects of sarafotoxin S6c on antidiuresis and norepinephrine overflow induced by stimulation of renal nerves in anesthetized dogs. J.Pharmacol.Exp.Ther. 280 905. PMID: 9023305.

Williams et al (1993) Characterization of cloned human endothelin receptors. Life Sci. 53 407. PMID: 8336519.

Williams et al (1991) Sarafotoxin S6c: an agonist which distinguishes between endothelin receptor subtypes. Biochem.Biophys.Res.Commun. 175 556. PMID: 1850245.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Sarafotoxin S6c include:

Hein et al (2009) Functional and molecular characterization of the endothelin system in retinal arterioles. Br J Pharmacol 50 3329. PMID: 19151386.

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Keywords: Sarafotoxin S6c, supplier, Selective, ETB, agonists, Receptors, Endothelin, SarafotoxinS6c, Tocris Bioscience, ETB Receptor Agonist products

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