Cat. No. 0337
Chemical Name: (S)-α-Methyl-4-carboxyphenylglycine
Biological ActivityActive isomer of (RS)-MCPG (Cat. No. 0336). Non-selective group I/group II metabotropic glutamate receptor antagonist. Also available as part of the Group I mGlu Receptor Tocriset™, Group II mGlu Receptor Tocriset™ and Mixed mGlu Receptor Tocriset™.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Bordi et al (1996) Effects of the metabotropic glutamate receptor antagonist MCPG on spatial and context-specific learning. Neuropharmacology 35 1557. PMID: 9025103.
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br. J. Pharmacol. 117 1493. PMID: 8730745.
Collingridge and Watkins (1994) Phenylglycine derivatives as metabotropic glutamate receptor antagonists. TiPS 15 333. PMID: 7992387.
Jane et al (1993) Stereospecific antagonism by (+)-α-methyl-4-carboxyphenylglycine (MCPG) of 1S,3R-ACPD induced effects in neonatal rat motoneurones and rat thalamic neurones. Neuropharmacology 32 725. PMID: 7689710.
If you know of a relevant reference for (S)-MCPG please let us know.
Citations are publications that use Tocris products. Selected citations for (S)-MCPG include:
Gu et al (2015) miR-26a and miR-384-5p are required for LTP maintenance and spine enlargement. Nat Commun 6 6789. PMID: 25858512.
Rosa et al (2015) Neuron-glia signaling in developing retina mediated by neurotransmitter spillover. J Neurosci 4. PMID: 26274565.
Stephen et al (2015) Miro1 Regulates Activity-Driven Positioning of Mitochondria within Astrocytic Processes Apposed to Synapses to Regulate Intracellular Calcium Signaling. Proc Natl Acad Sci U S A 35 15996. PMID: 26631479.
Szokol et al (2015) Augmentation of Ca(2+) signaling in astrocytic endfeet in the latent phase of temporal lobe epilepsy. Elife 9 49. PMID: 25762896.
Nieus et al (2014) Regulation of output spike patterns by phasic inhibition in cerebellar granule cells. Front Cell Neurosci 8 246. PMID: 25202237.
Akerboom et al (2012) Optimization of a GCaMP calcium indicator for neural activity imaging. J Neurosci 32 13819. PMID: 23035093.
Navarrete et al (2012) Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. PLoS Biol 10 e1001259. PMID: 22347811.
Platt et al (2012) Striatal dopamine transmission is subtly modified in human A53Tα-synuclein overexpressing mice. PLoS One 7 e36397. PMID: 22570709.
Ali (2011) CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1. J Neurophysiol 105 1051. PMID: 21123660.
Shinoda et al (2010) Persistent synapse loss induced by repetitive LTD in developing rat hippocampal neurons. PLoS One 5 e10390. PMID: 20436928.
Fukunaga et al (2007) Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Br J Pharmacol 151 870. PMID: 17502847.
Bender et al (2006) Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex. J Neurosci 26 4166. PMID: 16624937.
Melyan et al (2004) Metabotropic regulation of intrinsic excitability by synaptic activation of kainate receptors. J Neurosci 24 4530. PMID: 15140923.
Paladini et al (2003) Dopamine controls the firing pattern of dopamine neurons via a network feedback mechanism. Nat Neurosci 100 2866. PMID: 12604788.
Matthies et al (2000) Enhancement of glutamate release by L-fucose changes effects of glutamate receptor antagonists on long-term potentiation in the rat hippocampus. Learn Mem 7 227. PMID: 10940323.
Dunaevsky et al (1999) Developmental regulation of spine motility in the mammalian central nervous system. Proc Natl Acad Sci U S A 96 13438. PMID: 10557339.
Vogt and Nicoll (1999) Glutamate and gamma-aminobutyric acid mediate a heterosynaptic depression at mossy fiber synapses in the hippocampus. Proc Natl Acad Sci U S A 96 1118. PMID: 9927703.
Colwell et al (1996) Regulation of N-methyl-D-aspartate-induced toxicity in the neostriatum: a role for metabotropic glutamate receptors? Front Cell Neurosci 93 1200. PMID: 8577740.
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Keywords: (S)-MCPG, supplier, mGlur, Group, I, Receptors, mGlu1, mGlu5, mGluR1, mGluR5, Glutamate, Metabotropic, II, mGlu2, mGlu3, mGluR2, mGluR3, antagonists, Tocris Bioscience, Glutamate (Metabotropic) Group I Receptor Antagonist products