Tocrifluor T1117

Cat. No. 2540

Tocrifluor T1117 C56H53Cl2N7O5 [1186195-59-4]

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Chemical Name: N-(Piperidin-1-yl)-5-(4-(4-(3-(5-carboxamidotetramethylrhodaminyl)propyl))phenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide

Biological Activity

Fluorescent form of AM 251 (Cat. No. 1117). AM 251 conjugated with 5-carboxytetramethylrhodamine (5-TAMRA) that fluoresces at 543 nm excitation (590 nm emission). Displays GPR55 binding activity.

Technical Data

M.Wt:
974.97
Formula:
C56H53Cl2N7O5
Solubility:
Soluble to 10 mM in DMSO
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
1186195-59-4

Resources

Other Information

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Safety Data Sheet: View Safety Data Sheet

Bruno et al (2014) Beyond radio-displacement techniques for identification of CB1 ligands: the first application of a fluorescence-quenching assay. Sci.Rep. 4 3757. PMID: 24441508.

Sylantyev et al (2013) Cannabinoid- and lysophosphatidylinositol-sensitive receptor GPR55 boosts neurotransmitter release at central synapses. Proc.Natl.Acad.Sci.U.S.A. 110 5193. PMID: 23472002.

Daly et al (2010) Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br.J.Pharmacol. 159 787. PMID: 20136833.

Daly et al (2008) Visualisation of vascular cannabinoid receptors and their potential interaction with α1-adrenergic receptors. Vascular and Smooth Muscle Phys.Soc. Symposium.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Tocrifluor T1117 include:

Tortoriello et al (2013) Targeted lipidomics in Drosophila melanogaster identifies novel 2-monoacylglycerols and N-acyl amides. PLoS One 8 e67865. PMID: 23874457.

Daly et al (2010) Fluorescent ligand binding reveals heterogeneous distribution of adrenoceptors and 'cannabinoid-like' receptors in small arteries. Br J Pharmacol 159 787. PMID: 20136833.

Do you know of a great paper that uses Tocrifluor T1117 from Tocris? If so please let us know.

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Keywords: Tocrifluor T1117, supplier, fluorescent, CB1, receptor, ligands, Fluorescent, Probes, cannabinoids, Receptors, cb1r, cb2r, Tocris Bioscience, CB1 Receptor products

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