Cat. No. 1291
Chemical Name: N-[[(3R)-5-Chloro-3,4-dihydro-8-hyd
Biological ActivityMycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Gekle et al (2000) Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J.Pharmacol.Exp.Ther. 293 837. PMID: 10869383.
Chong and Rahimtula (1992) Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vitro. Biochem.Pharmacol. 44 1401. PMID: 1417961.
Dirheimer and Creppy (1991) Mechanism of action of ochratoxin A. IARC Sci.Publ. 115 171. PMID: 1820332.
Omar et al (1991) Role of cytochrome-P-450 in ochratoxin-A stimulated lipid-peroxidation. J.Biochem.Toxicol. 6 203. PMID: 1770504.
Merck Index 12 6836.
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