Ochratoxin A

Cat. No. 1291

Ochratoxin A C20H18ClNO6 [303-47-9]

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Chemical Name: N-[[(3R)-5-Chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl]carbonyl]-L-phenylalanine

Biological Activity

Mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump. Induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Stimulates lipid peroxidation.

Technical Data

M.Wt:
403.82
Formula:
C20H18ClNO6
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>99 %
Storage:
Desiccate at +4°C
CAS No:
303-47-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Gekle et al (2000) Ochratoxin A induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. J.Pharmacol.Exp.Ther. 293 837. PMID: 10869383.

Chong and Rahimtula (1992) Alterations in ATP-dependent calcium uptake by rat renal cortex microsomes following ochratoxin A administration in vitro. Biochem.Pharmacol. 44 1401. PMID: 1417961.

Dirheimer and Creppy (1991) Mechanism of action of ochratoxin A. IARC Sci.Publ. 115 171. PMID: 1820332.

Omar et al (1991) Role of cytochrome-P-450 in ochratoxin-A stimulated lipid-peroxidation. J.Biochem.Toxicol. 6 203. PMID: 1770504.

Merck Index 12 6836.

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