Domperidone

Cat. No. 2536

Domperidone C22H24ClN5O2 [57808-66-9]

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Alternative Name: R 33812

Chemical Name: 5-Chloro-1-[1-[3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl]-4-piperidinyl]-1,3-dihydro-2H-benzimidazol-2-one

Biological Activity

Peripheral dopamine D2-like receptor antagonist that does not readily cross the blood brain barrier. Displays gastroprokinetic and antiemetic properties; increases the frequency and duration of antral and duodenal contractions and protects from apomorphine-induced emesis (ED50 values are 0.003 and 0.03 mg/kg for i.v. and oral administration respectively).

Technical Data

M.Wt:
425.92
Formula:
C22H24ClN5O2
Solubility:
Soluble to 5 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
57808-66-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Osinski et al (2005) Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets. Pharmacol.Biochem.Behav. 81 211. PMID: 15894081.

Prakash and Wagstaff (1998) Domperidone. A review of its use in diabetic gastropathy. Drugs 56 429. PMID: 9777316.

Neimegeers et al (1980) The antiemetic effects of domperidone, a novel potent gastrokinetic. Arch.Int.Pharmacodyn.Ther. 244 130. PMID: 7416883.

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Keywords: Domperidone, supplier, Peripheral, D2-like, antagonists, Dopamine, Non-Selective, Receptors, dopaminergic, R33812, Tocris Bioscience, Non-selective Dopamine Antagonist products

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