Cat. No. 2534
Chemical Name: 4-[2-(Methylthio)phenyl]-N-(1,2,3,4
Biological ActivityHigh affinity 5-HT7 receptor agonist (Ki = 0.22 nM) that displays selectivity over 5-HT1A and 5-HT2A receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).
Licensing InformationSold under license from the University of Bari
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Leopoldo et al (2004) Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J.Med.Chem. 47 6616. PMID: 15588097.
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Keywords: LP 44, supplier, High, affinity, 5-HT7, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, LP44, Tocris Bioscience, 5-HT7 Receptor Agonist products