LP 44

Cat. No. 2534

LP 44 C27H37N3OS.HCl [824958-12-5]

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Chemical Name: 4-[2-(Methylthio)phenyl]-N-(1,2,3,4-tetrahydro-1-naphthalenyl)-1-piperazinehexanamide hydrochloride

Biological Activity

High affinity 5-HT7 receptor agonist (Ki = 0.22 nM) that displays selectivity over 5-HT1A and 5-HT2A receptors (200- and > 1000-fold respectively). Induces relaxation of substance P-stimulated guinea pig ileum (EC50 = 2.56 μM).

Licensing Information

Sold under license from the University of Bari

Technical Data

M.Wt:
488.13
Formula:
C27H37N3OS.HCl
Solubility:
Soluble to 100 mM in DMSO and to 75 mM in ethanol
Purity:
>98 %
Storage:
Desiccate at RT
CAS No:
824958-12-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Leopoldo et al (2004) Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents. J.Med.Chem. 47 6616. PMID: 15588097.

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Citations are publications that use Tocris products. Selected citations for LP 44 include:

Watts et al (2015) 5-HT is a potent relaxant in rat superior mesenteric veins. Mol Med 3 e00103. PMID: 25692021.

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Keywords: LP 44, supplier, High, affinity, 5-HT7, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, LP44, Tocris Bioscience, 5-HT7 Receptor Agonist products

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