Anisomycin

Cat. No. 1290

Anisomycin C14H19NO4 [22862-76-6]

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Chemical Name: (2R,3S,4S)-2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate

Biological Activity

Protein synthesis inhibitor (blocks translation). Potent activator of stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase. Acts as a potent signaling agonist to selectively elicit homologous desensitization of immediate early gene induction (c-fos, fosB, c-jun, junB and junD).

Technical Data

M.Wt:
265.31
Formula:
C14H19NO4
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at +4°C
CAS No:
22862-76-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Croons et al (2009) The protein synthesis inhibitor anisomycin induces macrophage apoptosis in rabbit atherosclerotic plaques through p38 mitogen-activated protein kinase. J.Pharmacol.Exp.Ther. 329 856. PMID: 19286921.

Hazzalin et al (1998) Anisomycin selectively desensitizes signalling components involved in stress kinase activation and fos and jun induction. Mol.Cell.Biol. 18 1844. PMID: 9528756.

Cano et al (1994) Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and -2 are implicated in the induction of c-fos and c-jun. Mol.Cell.Biol. 14 7352. PMID: 7935449.

Kyriakis et al (1994) The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369 156. PMID: 8177321.

Sanchez et al (1994) Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372 794. PMID: 7997269.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Anisomycin include:

Dieck et al (2015) Direct visualization of newly synthesized target proteins in situ. Nat Methods 12 411. PMID: 25775042.

Basu et al (2014) Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells. Autophagy 10 1193. PMID: 24813396.

Wang et al (2014) SynGAP regulates protein synthesis and homeostatic synaptic plasticity in developing cortical networks. PLoS One 8 e83941. PMID: 24391850.

Ma et al (2013) Suppression of eIF2α kinases alleviates Alzheimer's disease-related plasticity and memory deficits. Nat Neurosci 16 1299. PMID: 23933749.

Fortin et al (2012) Brain-derived neurotrophic factor activation of CaM-kinase kinase via transient receptor potential canonical channels induces the translation and synaptic incorporation of GluA1-containing calcium-permeable AMPA receptors. J Neurosci 32 8127. PMID: 22699894.

Hays et al (2011) Altered neocortical rhythmic activity states in Fmr1 KO mice are due to enhanced mGluR5 signaling and involve changes in excitatory circuitry. J Neurosci 31 14223. PMID: 21976507.

Fuortes et al (2010) Distinctions between persistent and reversible group I mGluR-induced epileptiform burst prolongation. Epilepsia 51 1633. PMID: 20659148.

Zhong et al (2009) BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability. J Neurosci 29 9977. PMID: 19675232.

Do you know of a great paper that uses Anisomycin from Tocris? If so please let us know.show all ▼show less ▲

View Related Products by Product Action

Keywords: Anisomycin, supplier, Protein, synthesis, inhibitors, inhibits, blocks, blocker, translation, activates, Activator, JNK, stress-activated, SAPK, p38, MAP, protein, kinases, MAPK, Signaling, Signalling, c-Jun, N-Terminal, Kinase, Mitogen-Activated, antibiotics, Tocris Bioscience, JNK/c-Jun Activator products

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