Zinterol hydrochloride

Cat. No. 1051

Zinterol hydrochloride C19H26N2O4S [37000-20-7]

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Alternative Name: MJ 9184

Chemical Name: N-[5-[2-[(1,1-Dimethyl-2-phenylethyl)amino]-1-hydroxyethyl]-2-hydroxyphenyl]methanesulphonamide hydrochloride

Biological Activity

Potent and selective β2-adrenoceptor agonist (pKB values are 8.3 and < 5.7 for β 2 and β1 receptors respectively, as measured in human artery).

Technical Data

M.Wt:
414.95
Formula:
C19H26N2O4S
Solubility:
Soluble to 5 mM in water and to 100 mM in DMSO
Purity:
>98 %
Storage:
Store at +4°C
CAS No:
37000-20-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Hutchinson et al (2006) Agonist effects of zinterol at the mouse and human β3-adrenoceptor. Naunyn Schmiedebergs Arch.Pharmacol. 373 158. PMID: 16601951.

Arvydas Skeberdis et al (1997) Beta-2 adrenergic activation of L-type Ca2+ current in cardiac myocytes. J.Pharmacol.Exp.Ther. 283 452. PMID: 9353357.

Kauman (1997) Four β-adrenoceptor subtypes in the mammalian heart. TiPS 18 70. PMID: 9133774.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products. Selected citations for Zinterol hydrochloride include:

Macdougall et al (2012) Caveolae compartmentalise β2-adrenoceptor signals by curtailing cAMP production and maintaining phosphatase activity in the sarcoplasmic reticulum of the adult ventricular myocyte. J Mol Cell Cardiol 52 388. PMID: 21740911.

Eckle et al (2008) A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Am Coll Cardiol 118 3301. PMID: 18787641.

Do you know of a great paper that uses Zinterol hydrochloride from Tocris? If so please let us know.

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Keywords: Zinterol hydrochloride, supplier, Selective, α2-adrenoceptor, beta2-adrenoceptor, b2-adrenoceptor, β2-adrenergic, α2-adrenergic, beta2-adrenergic, b2-adrenergic, agonists, Receptors, MJ9184, Tocris Bioscience, Adrenergic β2 Receptor Agonist products

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