Cat. No. 2531
Alternative Name: CCD 1042
Chemical Name: (3α,5α)-3-Hydroxy-3-methyl-pregnan-20
Biological ActivityPotent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
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All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Lyden et al (2000) Effect of ganaxolone in a rodent model of cerebral hematoma. Stroke 31 169. PMID: 10625734.
Ungard et al (2000) Modification of behavioral effects of drugs in mice by neuroactive steroids. Psychopharmacology 148 336. PMID: 10928304.
Carter et al (1997) Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high affinity, steroid modulator of the γ-aminobutyric acidA receptor. J.Pharmacol.Exp.Ther. 280 1284. PMID: 9067315.
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Keywords: Ganaxolone, supplier, Potent, positive, allosteric, modulators, GABAA, receptors, Receptors, CCD1042, Tocris Bioscience, GABAA Receptor Modulator products
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