Cat. No. 2531
Alternative Name: CCD 1042
Chemical Name: (3α,5α)-3-Hydroxy-3-methyl-pregnan-20
Biological ActivityPotent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Lyden et al (2000) Effect of ganaxolone in a rodent model of cerebral hematoma. Stroke 31 169. PMID: 10625734.
Ungard et al (2000) Modification of behavioral effects of drugs in mice by neuroactive steroids. Psychopharmacology 148 336. PMID: 10928304.
Carter et al (1997) Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high affinity, steroid modulator of the γ-aminobutyric acidA receptor. J.Pharmacol.Exp.Ther. 280 1284. PMID: 9067315.
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Keywords: Ganaxolone, supplier, Potent, positive, allosteric, modulators, GABAA, receptors, Receptors, CCD1042, Tocris Bioscience, GABAA Receptor Modulator products