Ganaxolone

Cat. No. 2531

Ganaxolone C22H36O2 [38398-32-2]

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Alternative Name: CCD 1042

Chemical Name: (3α,5α)-3-Hydroxy-3-methyl-pregnan-20-one

Biological Activity

Potent positive allosteric modulator of GABAA receptors. Enhances GABA-evoked chloride currents in Xenopus oocytes expressing GABAA receptors (EC50 values are 94, 122 and 213 nM for α2β1γ2L, α3β1γ2L and α1β1γ2L receptors respectively). Exerts anticonvulsive effects in a broad range of animal seizure models.

Technical Data

M.Wt:
332.53
Formula:
C22H36O2
Solubility:
Soluble to 10 mM in DMSO with gentle warming and to 20 mM in ethanol
Storage:
Store at +4°C
CAS No:
38398-32-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Lyden et al (2000) Effect of ganaxolone in a rodent model of cerebral hematoma. Stroke 31 169. PMID: 10625734.

Ungard et al (2000) Modification of behavioral effects of drugs in mice by neuroactive steroids. Psychopharmacology 148 336. PMID: 10928304.

Carter et al (1997) Characterization of the anticonvulsive properties of ganaxolone (CCD 1044; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high affinity, steroid modulator of the γ-aminobutyric acidA receptor. J.Pharmacol.Exp.Ther. 280 1284. PMID: 9067315.

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Keywords: Ganaxolone, supplier, Potent, positive, allosteric, modulators, GABAA, receptors, Receptors, CCD1042, Tocris Bioscience, GABAA Receptor Modulator products

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