AH 11110 hydrochloride

Cat. No. 0998

AH 11110 hydrochloride C21H26N2O2.HCl [179388-65-9]

Price and Availability

For AH 11110 hydrochloride pricing & availability please select your country from the drop down menu:
Submit
By clicking submit you agree to accept a cookie from Tocris Bioscience. For details, please read our privacy and cookie policy.

Chemical Name: 4-Imino-1-(2-phenylphenoxy)-4-piperidinebutan-2-ol hydrochloride

Biological Activity

A subtype-selective ligand for the α1B-adrenoceptor. The pKi values for binding to rat fibroblast cell membranes expressing α1B (hamster), α1A (bovine) and α1D (rat) are 7.1, 5.59, and 5.68 respectively. Appears to be non-selective between α1 subtypes and α2 receptors in smooth muscle preparations.

Technical Data

M.Wt:
374.91
Formula:
C21H26N2O2.HCl
Solubility:
Soluble to 25 mM in water
Purity:
>98 %
Storage:
Store at RT
CAS No:
179388-65-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Eltze et al (2001) Failure of AH11110A to functionally discriminate between α1-adrenoceptor subtypes A, B and D or between α1- and α2-adrenoceptors. Eur.J.Pharmacol. 415 265. PMID: 11275009.

Saussy et al (1996) Structure-activity relationships of a series of buspirone analogs at alpha-1 adrenoceptors: further evidence that rat aorta alpha-1 adrenoceptors are of the alpha-1D subtype. J.Pharmacol.Exp.Ther. 278 136. PMID: 8764344.

King et al (1994) AH 11110A is selective for the α1B-subtype of α1-adrenoceptors. Soc.Neurosci.Abstr. 20 526.

If you know of a relevant reference for this product please let us know.

Citations are publications that use Tocris products.

Do you know of a great paper that uses AH 11110 hydrochloride from Tocris? If so please let us know.

View Related Products by Target

View Related Products by Product Action

Keywords: AH 11110 hydrochloride, supplier, Subtype-selective, α1B-adrenoceptor, alpha1B-adrenoceptor, α1b-adrenergic, alpha1b-adrenergic, a1b-adrenoceptor, a1b-adrenergic, ligands, Receptors, AH11110, hydrochloride, Tocris Bioscience, Adrenergic α1 Receptor Ligand products

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

divider line

Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

divider line

New Products in this Area

AdTx1

Selective, high affinity, non-competitive α1A adrenoceptor antagonist

Sign-up for new product e-alerts
divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.