Cat. No. 2530
Chemical Name: (2S*,3R*)-1-(Phenanthren-2-carbonyl
Biological ActivitySubtype-selective NMDA receptor antagonist that preferentially binds to NR2C/NR2D-containing receptors (Ki values are 0.096, 0.125, 0.31 and 0.55 μM for NR2C, NR2D, NR2B and NR2A subunits respectively).
Licensing InformationSold under license from UNeMed Corporation.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Datasheet
References are publications that support the products' biological activity.
Kinarsky et al (2005) Identification of subunit- and antagonist-specific amino acid residues in the N-methyl-D-aspartate receptor glutamate-binding pocket. J.Pharmacol.Exp.Ther. 313 1066. PMID: 15743930.
Morley et al (2005) Synthesis and pharmacology of N1-substituted piperazine-2,3-dicarboxylic acid derivatives acting as NMDA receptor antagonists. J.Med.Chem. 48 2627. PMID: 15801853.
Feng et al (2004) Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl)piperazine-2,3-dicarboxylic acid. Br.J.Pharmacol. 141 508. PMID: 14718249.
If you know of a relevant reference for PPDA please let us know.
Citations are publications that use Tocris products. Selected citations for PPDA include:
Mirante et al (2014) Distinct molecular components for thalamic- and cortical-dependent plasticity in the lateral amygdala. Autophagy 7 62. PMID: 25071439.
Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144. PMID: 24062647.
Do you know of a great paper that uses PPDA from Tocris? If so please let us know.
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Keywords: PPDA, supplier, Subtype-selective, NR2C/NR2D, antagonists, Glutamate, NMDA, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, cis-ppda, Tocris Bioscience, NMDA Receptor Antagonist products