KT 5823

Cat. No. 1289

KT 5823 C29H25N3O5 [126643-37-6]

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Chemical Name: (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-2,9-dimethyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, methyl ester

Biological Activity

Selective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.

Technical Data

M.Wt:
495.53
Formula:
C29H25N3O5
Solubility:
Soluble to 50 mM in DMSO
Purity:
>98 %
Storage:
Desiccate at -20°C
CAS No:
126643-37-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Smolenski et al (1998) Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch.Pharmacol. 358 134. PMID: 9721015.

Murthy and Makhlouf (1995) Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells. Am.J.Physiol. 268 C171. PMID: 7840145.

Gadbois et al (1992) Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 89 8626. PMID: 1528872.

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Citations are publications that use Tocris products. Selected citations for KT 5823 include:

Becker et al (2014) Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 141 335. PMID: 24353062.

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Keywords: KT 5823, supplier, Selective, protein, kinases, G, inhibitors, inhibits, PKG, cGMP, KT5823, Tocris Bioscience, Protein Kinase G Inhibitor products

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