Cat. No. 1289
Chemical Name: (9S,10R,12R)-2,3,9,10,11,12-Hexahyd
Biological ActivitySelective inhibitor of protein kinase G (Ki values are 0.23, 4 and > 10 μM for inhibition of PKG, PKC and PKA respectively). Inhibits SNP-stimulated PKG activity with an IC50 of 60 nM in dispersed smooth muscle cells and has little effect on PKA activity at concentrations of up to 10 μM.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Smolenski et al (1998) Functional analysis of cGMP-dependent protein kinases I and II as mediators of NO/cGMP effects. Naunyn Schmiedebergs Arch.Pharmacol. 358 134. PMID: 9721015.
Murthy and Makhlouf (1995) Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells. Am.J.Physiol. 268 C171. PMID: 7840145.
Gadbois et al (1992) Multiple kinase arrest points in the G1 phase of nontransformed mammalian cells are absent in transformed cells. Proc.Natl.Acad.Sci.U.S.A. 89 8626. PMID: 1528872.
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Citations are publications that use Tocris products. Selected citations for KT 5823 include:
Becker et al (2014) Differential activation of natriuretic peptide receptors modulates cardiomyocyte proliferation during development. Development 141 335. PMID: 24353062.
Giricz et al (2009) Hyperlipidaemia induced by a high-cholesterol diet leads to the deterioration of guanosine-3',5'-cyclic monophosphate/protein kinase G-dependent cardioprotection in rats. J Neurosci 158 1495. PMID: 19845676.
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Keywords: KT 5823, supplier, Selective, protein, kinases, G, inhibitors, inhibits, PKG, cGMP, KT5823, Tocris Bioscience, Protein Kinase G Inhibitor products
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