YM 26734

Cat. No. 2522

YM 26734 C45H62O8 [144337-18-8]

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Chemical Name: 1,1'-[5-[3,4-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-2H-1-benzopyran-4-yl]-2,4,6-trihydroxy-1,3-phenylene]bis-1-dodecanone

Biological Activity

Competitive inhibitor of secretory phospholipase A2 (sPLA2) that exhibits a broad inhibitory profile to several sPLA2s (IC50 values are 0.2, 1, 1, 1 and 3 μM for sPLA2-X, -IIA, -IID, -V and -IIE respectively). Displays minimal activity at sPLA2-IIF and no activity at cytosolic PLA2, cyclooxygenase and lipoxygenase. Ameliorates local inflammatory responses in TPA-induced mouse ear edema.

Technical Data

M.Wt:
730.97
Formula:
C45H62O8
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
>95 %
Storage:
Store at -20°C
CAS No:
144337-18-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

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Hamaguchi et al (2003) Induction of distinct sets of secretory phospholipase A2 in rodents during inflammation. Biochim.Biophys.Acta 1635 37. PMID: 14642775.

Miyake et al (1994) Exogenous group II phospholipase A2 prostaglandin E2 production in mouse peritoneal macrophages. Eur.J.Pharmacol. 253 155. PMID: 8013541.

Miyake et al (1993) Suppression of inflammatory responses to 12-O-tetradecanoyl-phorbol-13-acetate and carregeenin by YM-26734, a selective inhibitor of extracellular group II phospholipase A2. Br.J.Pharmacol. 110 447. PMID: 8220906.

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Citations are publications that use Tocris products. Selected citations for YM 26734 include:

Pernet et al (2014) Pseudomonas aeruginosa eradicates Staphylococcus aureus by manipulating the host immunity. Nat Commun 5 5105. PMID: 25290234.

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Keywords: YM 26734, supplier, Secretory, phospholipases, A2, sPLA2, inhibitors, inhibits, Esterases, YM26734, Tocris Bioscience, Phospholipase Inhibitor products

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