NSC 3852

Cat. No. 2521

NSC 3852 C9H6N2O2 [3565-26-2]

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Chemical Name: 5-Nitroso-8-quinolinol

Biological Activity

Histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo.

Technical Data

M.Wt:
174.16
Formula:
C9H6N2O2
Solubility:
Soluble to 100 mM in DMSO and to 10 mM in ethanol
Storage:
Store at RT
CAS No:
3565-26-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

Martirosyan et al (2006) Actions of a histone deacetylase inhibitor NSC3852 (5-nitroso-8-quinolinol) link reactive oxygen species to cell differentiation and apoptosis in MCF-7 human mammary tumor cells. J.Pharmacol.Exp.Ther. 317 546. PMID: 16497787.

Martirosyan et al (2004) Differentiation-inducing quinolines as experimental breast cancer agents in the MCF-7 human breast cancer cell model. Biochem.Pharmacol. 68 1729. PMID: 15450938.

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Keywords: NSC 3852, supplier, Histone, deacetylases, inhibitors, inhibits, HDAC, NSC3852, epigenetics, Tocris Bioscience, Histone Deacetylase Inhibitor products

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