TC 1698 dihydrochloride
Cat. No. 2518
Chemical Name: 2-(3-Pyridinyl)-1-azabicyclo[3.2.2]
Biological ActivitySelective nicotinic α7 receptor agonist (EC50 = 440 nM). Also displays weak partial agonist/antagonist activity at β-subunit-containing receptors. Neuroprotective.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Safety Data Sheet
Papke et al (2005) Rhesus monkey α7 nicotinic acetylcholine receptors: comparisons to human α7 receptors expressed in Xenopus oocytes. Eur.J.Pharmacol. 524 11. PMID: 16266703.
Marrero et al (2004) The neuroprotective effect of 2-(3-Pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel α7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J.Pharmacol.Exp.Ther. 309 16. PMID: 14722323.
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November 12 - 16, 2016
San Diego, CA, USA