FG 7142

Cat. No. 0554

FG 7142 C13H11N3O [78538-74-6]

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Chemical Name: N-Methyl-β-carboline-3-carboxamide

Biological Activity

Inverse agonist and anxiogenic agent. Increases tyrosine hydroxylation and causes upregulation of β-adrenoceptors in mouse cerebral cortex.

Technical Data

M.Wt:
225.25
Formula:
C13H11N3O
Solubility:
Soluble to 75 mM in 1eq. HCl and to 100 mM in DMSO
Purity:
>99 %
Storage:
Store at RT
CAS No:
78538-74-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Certificate of Analysis / Product Datasheet
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Donner et al (1989) Evidence for an excitatory action of benzodiazepine receptor inverse agonist FG 7142 on C-fibre afferents. Naunyn Schmiedebergs Arch.Pharmacol. 340 352. PMID: 2478895.

Knorr et al (1989) The anxiogenic β-carboline FG-7142 increases in vivo and in vitro tyrosine hydroxylation in the prefrontal cortex. Brain Res. 495 355. PMID: 2765936.

Wettstei (1989) Behavioural studies with the β-carboline FG 7142 combined with related drugs in monkeys. Eur.J.Pharmacol. 163 219. PMID: 2498110.

Stanford et al (1987) A single dose of FG 7142 causes long term increases in mouse cortical β-adrenoceptors. Eur.J.Pharmacol. 134 313. PMID: 3032657.

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Citations are publications that use Tocris products. Selected citations for FG 7142 include:

Johnson et al (2012) Orexin 1 receptors are a novel target to modulate panic responses and the panic brain network. Life Sci 107 733. PMID: 22554617.

Lukkes et al (2012) Post-weaning social isolation attenuates c-Fos expression in GABAergic interneurons in the basolateral amygdala of adult female rats. Physiol Behav 107 719. PMID: 22583860.

Lukkes et al (2012) Post-weaning social isolation of female rats, anxiety-related behavior, and serotonergic systems. Brain Res 1443 1. PMID: 22297173.

Major et al (2009) The anxiogenic drug FG7142 increases self-injurious behavior in male rhesus monkeys (Macaca mulatta). J Neurosci 85 753. PMID: 19837095.

Do you know of a great paper that uses FG 7142 from Tocris? If so please let us know.show all ▼show less ▲

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Keywords: FG 7142, supplier, Benzodiazepine, inverse, agonists, GABAA, Receptors, FG7142, Tocris Bioscience, GABAA Receptor Benzodiazepine products

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