CGS 35066

Cat. No. 2512

CGS 35066 C16H16NO6P [261619-50-5]

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Chemical Name: α-[(S)-(Phosphonomethyl)amino]-3-dibenzofuranpropanoic acid

Biological Activity

Potent endothelin-converting enzyme (ECE) inhibitor that displays > 100-fold selectivity over neutral endopeptidase 24.11 (IC50 values are 22 and 2300 nM respectively). Blocks the hypertensive effects induced by big ET-1 in vitro and reduces the magnitude of cerebral vasospasm following subarachnoid hemorrhage (SAH).

Technical Data

M.Wt:
349.28
Formula:
C16H16NO6P
Solubility:
Soluble to 100 mM in 1eq. NaOH
Purity:
>99 %
Storage:
Desiccate at RT
CAS No:
261619-50-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Data Sheet

Kwan et al (2002) Attenuation of SAH-induced cerebral vasospasm by a selective ECE inhibitor. Neuropharmacol.Neurotoxicol. 13 197.

De Lombaert et al (2000) Potent and selective non-peptidic inhibitors of endothelin-converting enzyme-1 with sustained duration of action. J.Med.Chem. 43 488. PMID: 10669576.

Trapani et al (2000) Pharmacological properties of CGS 35066, a potent and selective endothelin-converting enzyme inhibitor, in conscious rats. J.Cardiovasc.Pharmacol. 36 (5 Suppl. 1) S40. PMID: 11078331.

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Keywords: CGS 35066, supplier, Endothelin-converting, enzyme, ECE, inhibitors, inhibits, Proteases, Proteinases, CGS35066, Tocris Bioscience, Other Protease Inhibitor products

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