APC 366

Cat. No. 2511

APC 366 N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide

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Chemical Name: N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide

Biological Activity

Selective inhibitor of mast cell tryptase (Ki = 7.1 μM) that inhibits tryptase-induced histamine release from human tonsil and lung cells. Reduces airway inflammation and blocks postchallenge airway hyperresponsiveness in vivo.

Technical Data

M.Wt:
440.5
Formula:
C22H28N6O4
Sequence:
N-(1-Hydroxy-2-naphthoyl)-L-arginyl-L-prolinamide
Solubility:
Soluble to 5 mg/ml in 20% ethanol / water
Storage:
Store at -20°C
CAS No:
158921-85-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Product Datasheet / Safety Datasheet

References are publications that support the products' biological activity.

He et al (2004) Inhibitors of tryptase as mast cell-stabilizing agents in the human airways: effects of tryptase and other agonists of proteinase-activated receptor 2 on histamine release. J.Pharmacol.Exp.Ther. 309 119. PMID: 14722328.

Barrios et al (1998) Tryptase mediates hyperresponsiveness in isolated guinea pig bronchi. Life Sci. 63 2295. PMID: 9877219.

He et al (1998) A role for tryptase in the activation of human mast cells: modulation of histamine release by tryptase and inhibitors of tryptase. J.Pharmacol.Exp.Ther. 286 289. PMID: 9655871.

Numerof et al (1997) Tryptase inhibitors: a novel class of anti-inflammatory drugs. Exp.Opin.Invest.Drugs. 6 811.

If you know of a relevant reference for APC 366 please let us know.

Citations are publications that use Tocris products. Selected citations for APC 366 include:

Matsuda et al (2015) Comparative Study on the Cytoprotective Effects of Activated Protein C Treatment in Nonsteatotic and Steatotic Livers under Ischemia-Reperfusion Injury. Am J Transl Res 2015 635041. PMID: 26539519.

Do you know of a great paper that uses APC 366 from Tocris? If so please let us know.

View Related Products by Product Action

Keywords: APC 366, supplier, Tryptase, inhibitors, inhibits, mast, cell, Proteases, Proteinases, PAR, Receptors, Protease-Activated, proteinase-activated, APC366, Tocris Bioscience, Protease-Activated Receptor Inhibitor products

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