Cat. No. 2506
Chemical Name: 2-[[6-Methoxy-4-(1-methylethyl)-1,1
Biological ActivityHigh affinity, potent inhibitor of human leukocyte elastase (HLE) (IC50 = 3.9 nM). Displays species-selectivity (Ki values are 0.017, 1.70, 3.01, 58 and > 100 nM for human, mouse, rat, rabbit and porcine elastase respectively). Inhibits HLE-induced lung hemorrhage in mice (ID50 = 2.8 mg/kg) and reduces infarct size in an in vivo acute model of coronary ischemia-reperfusion injury. Orally active.
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Certificate of Analysis / Product Datasheet / Safety Data Sheet
Bidouard et al (2003) SSR69071, an elastase inhibitor, reduces myocardial infarct size following ischemia-reperfusion injury. Eur.J.Pharmacol. 461 49. PMID: 12568915.
Kapui et al (2003) Biochemical and pharmacological characterization of 2-(9-(2-Piperidinoethoxy)-4-oxo-4H-pyrido[1,2-α]pyrimidin-2-yloxymethyl)-4-(1-methylethyl)-6-methoxy-1,2-benzisothiazol-3(2H)-one-1,1-dioxide (SSR69071), a novel, orally active elastase inhibitor. J.Pharmacol.Exp.Ther. 305 451. PMID: 12606659.
Varga et al (2003) A novel orally active inhibitor of HLE. Eur.J.Med.Chem. 38 421. PMID: 12750030.
If you know of a relevant reference for this product please let us know.
Citations are publications that use Tocris products. Selected citations for SSR 69071 include:
Li et al (2013) Solar ultraviolet irradiation induces decorin degradation in human skin likely via neutrophil elastase. PLoS One 8 e72563. PMID: 24023624.
Hoffmann et al (2011) Pivotal role for alpha1-antichymotrypsin in skin repair. J Biol Chem 286 28889. PMID: 21693707.
Do you know of a great paper that uses SSR 69071 from Tocris? If so please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: SSR 69071, supplier, Potent, orally, active, human, leukocyte, elastase, inhibitors, inhibits, Neutrophil, Proteinases, Proteases, SSR69071, HLE, inhibitor, Tocris Bioscience, Elastase Inhibitor products
Find multiple products by catalog number
New Products in this Area
Potent 20S proteasome inhibitorDiprotin A
Dipeptidyl peptidase IV (DPP-IV) inhibitorAcein
High affinity angiotensin-converting enzyme (ACE) ligandTMI 1
Adam 17 (TACE) and MMP inhibitor; orally bioavailableRitonavir
HIV-1 and HIV-2 protease inhibitor
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.