Nonactin

Cat. No. 2505

Nonactin C40H64O12 [6833-84-7]

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Alternative Name: Ammonium Ionophore I

Chemical Name: (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone

Biological Activity

Monovalent cation ionophore that displays selectivity for K+ and NH4+ (K+ = NH4+ > Na+ > Mg2+ > Li+ >> Ca2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.

Technical Data

M.Wt:
736.94
Formula:
C40H64O12
Solubility:
Soluble to 10 mM in ethanol
Purity:
>93 %
Storage:
Desiccate at -20°C
CAS No:
6833-84-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.

Certificate of Analysis / Safety Data Sheet

Certificate of Analysis: View current batch
Safety Data Sheet: View Safety Data Sheet

Garcia et al (2003) Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occluded in EVA membrane. J.Pharm.Biomed.Anal. 31 11. PMID: 12560044.

Woo et al (1999) Nonactin biosynthesis: the product of nonS catalyzes the formation of the furan ring of nonactic acid. Antimicrob.Agents Chemother. 43 1662. PMID: 10390219.

Borrel et al (1994) Mobile ionophores are a novel class of P-glycoprotein inhibitors. The effects of ionophores on 4'O-tetrahydropyranyl-adriamycin incorporation in K562 drug-resistant cells. Eur.J.Biochem. 223 125. PMID: 7518390.

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Keywords: Nonactin, supplier, Monovalent, cation, ionophores, NH4+, K+, Potassium, antibiotics, Tocris Bioscience, Ionophore products

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